Investigation of Cognitive Function Before and After Induced Ventricular Fibrillation in Electrophysiological (EP) Study

This study is currently recruiting participants.

Verified by University of Heidelberg, November 2004

Sponsored by:	University of Heidelberg
Information provided by:	University of Heidelberg
ClinicalTrials.gov Identifier:	NCT00176176

Purpose

In this study, changes in electroencephalogram (EEG) and the hemodynamic state during ventricular fibrillation or induced ventricular tachycardia are investigated.

Condition	Intervention
Ventricular Fibrillation Ventricular Tachycardia	Device: EEG

Genetics Home Reference related topics: Brugada syndrome short QT syndrome

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Diagnostic, Non-Randomized, Open Label, Uncontrolled, Single Group Assignment, Efficacy Study
Official Title:	Change of EEG Activity and Cerebral Circulation During Induced Ventricular Fibrillation and Investigation of Cognitive Function Before and After Induced Ventricular Fibrillation in EP Study

Further study details as provided by University of Heidelberg:

Estimated Enrollment:

Detailed Description:

Patients with a high risk of malignant tachyarrhythmia are routinely investigated by programmed electrophysiological study (EPS). To investigate the hemodynamic effects of ventricular arrhythmia to cerebral circulation an EEG and transcranial ultrasound are conducted simultaneously during the EPS. Before and after the EPS a neuropsychological test and an investigation of a specific blood sample (Neuron Specific Enolase, NSE) is done.

Eligibility

Ages Eligible for Study:	18 Years and older
Genders Eligible for Study:	Both

Criteria

Inclusion Criteria:

Age > 18 years
Positive agreement
EPS for primary and secondary prophylaxis of a malignant ventricular tachyarrhythmia:
- primary prophylaxis: Brugada syndrome, long QT syndrome, cardiomyopathy, short QT syndrome
- secondary prophylaxis: Multicenter Automatic Defibrillator Implantation Trial (MADIT) criteria, syncope, documented ventricular tachycardia

Exclusion Criteria:

Severe neurological deficit
Cardiopulmonary resuscitation

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00176176

Contacts

Contact: Christian Wolpert, PD, MD

+49-621-383-2206

christian.wolpert@med.ma. uni-heidelberg.de

Locations

Germany
Fakultät für Klinische Medizin Mannheim Universitätsklinikum Mannheim der Ruprecht-Karls-Universität Heidelberg	Recruiting
Mannheim, Germany, 68167
Contact: Christian Wolpert, PD, MD +49-621-383-2206 christian.wolpert@med.ma. uni-heidelberg.de
Principal Investigator: Constanze M Echternach, MD

Sponsors and Collaborators

University of Heidelberg

Investigators

Study Director:	Martin Borggrefe, Prof., MD	I. Medizinische Klinik Universitätsklinikum Mannheim
Study Director:	M Hennerici, Prof., MD	Neurologische Klinik Universitätsklinikum Mannheim

More Information

Study ID Numbers:	235/04
Study First Received:	September 13, 2005
Last Updated:	October 11, 2006
ClinicalTrials.gov Identifier:	NCT00176176
Health Authority:	Germany: Ethics Commission

Keywords provided by University of Heidelberg:

cerebral circulation

Study placed in the following topic categories:

Heart Diseases
Tachycardia
Paroxysmal ventricular fibrillation

Tachycardia, Ventricular
Ventricular Fibrillation
Arrhythmias, Cardiac

Additional relevant MeSH terms:

Pathologic Processes
Cardiovascular Diseases

ClinicalTrials.gov processed this record on January 16, 2009