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Abstract

Title: Dietary fat and risk of renal cell carcinoma in the USA: a case-control study.
Author: Brock KE,Gridley G,Chiu BC,Ershow AG,Lynch CF,Cantor KP
Journal: Br J Nutr :1-11
Year: 2008
Month: September

Abstract: An increased risk of renal cell carcinoma (RCC) has been linked with obesity. However, there is limited information about the contribution of dietary fat and fat-related food groups to RCC risk. A population-based case85 years was conducted in Iowa (1986% CI, adjusting for age, sex, smoking, obesity, hypertension, physical activity, alcohol and vegetable intake and tea and coffee consumption. In all nutrient analyses, energy density estimates were used. Dietary nutrient intake of animal fat, saturated fat, oleic acid and cholesterol was associated with an elevated risk of RCC (OR1% CI 19, Ptrend0=6, 956, 4<001; OR1% CI 19, Ptrend0=9, 953, 2=006, respectively, for the top quartile compared with the bottom quartile of intake). Increased risks were also associated with high-fat spreads, red and cured meats and dairy products (OR2% CI 10, Ptrend0=7, 950, 2=01; OR1% CI 17, Ptrend0=6, 951, 2=02, respectively). In both the food groups and nutrients, there was a significant dose-response with increased intake. Our data also indicated that the association of RCC with high-fat spreads may be stronger among individuals with hypertension. These findings deserve further investigation in prospective studies.