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Abstract

Title: Effect of CCR5-Delta32 Heterozygosity on the Risk of Perinatal HIV-1 Infection: A Meta-Analysis.
Author: Contopoulos-Ioannidis DG, O'Brien TR, Goedert JJ, Rosenberg PS, Ioannidis JP
Journal: J Acquir Immune Defic Syndr 32(1):70-76
Year: 2003
Month: January

Abstract: Several studies have investigated whether heterozygosity for a 32-basepair deletion in the CC chemokine receptor 5 gene ( ) affects susceptibility to perinatal HIV-1 infection, but results have been inconclusive. We performed a meta-analysis of published data from 11 studies of HIV-1 perinatally exposed children who were genotyped for the polymorphism. The crude overall HIV-1 infection rates, by simple data pooling, were 20% (one of five) among homozygote children, 39% (131 of 335) among heterozygote children, and 40% (1408 of 3526) among wild-type homozygote children. Compared with wild-type homozygotes, the random effects risk ratio for heterozygotes was 1.04 (95% confidence interval [CI], 0.92-1.17) among all children ( = 3861) and 1.03 (95% CI, 0.90-1.17) among those of European descent ( = 2890). Results were similar when adjusted for the available data on the polymorphism ( = 1542). The meta-analysis clarifies that perinatal infection is not significantly altered by heterozygosity for in the child.