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Title: Physical activity and risk of endometrial cancer in a prospective cohort study (United States).
Author: Colbert LH, Lacey JV, Schairer C, Albert P, Schatzkin A, Albanes D
Journal: Cancer Causes Control 14(6):559-567
Year: 2003
Month: August

Abstract: Objective: To examine the physical activity and endometrial cancer relationship in a prospective study of US women enrolled in the Breast Cancer Detection Demonstration Project (BCDDP) Follow-up Study.Methods: We assessed past-year physical activity of all types in 23,369 women who returned the baseline questionnaire (1987-1989) and had no prior hysterectomy and/or endometrial cancer. Cox proportional hazards models were used to estimate age, education, and parity-adjusted rate ratios (RR) and 95% confidence intervals (CI) for the 253 confirmed endometrial cancer cases identified during an average 8.2 years of follow-up (ending 1995 1998).Results: There were no dose-response relationships with either total or vigorous physical activity; however, compared to the lowest total activity quartile, the higher four quartiles had a non-significantly lower risk (RR = 0.8,CI = 0.6-1.0). The association with moderate activity varied with follow-up time: RRs (CI) for a 1 h increase in daily moderate activity within 2-year intervals of follow-up (less than or equal to2, 2.1-4.9, 5.0-8.0, >8 years) were 1.1 (1.0, 1.2), 1.0 (0.9, 1.1), 1.0 (0.9,1.1), 1.0 (0.9, 1.1), and 0.8 (0.7, 1.0), respectively.Conclusion: These data suggest that recent physical activity is not strongly related to the risk of endometrial cancer, and that prolonged exposure and longer follow-up may be necessary.