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National Cancer Institute U.S. National Institutes of Health
Tools & Resources

MultAssoc is a MATLAB software package for test of association of a disease with a group of SNPs after accounting for their interaction with another group of SNPs or environmental exposures. In addition to implementing two standard logistic regression based tests, the package implements a novel method, called TukAssoc, that uses the Tukey’s 1 d.f. model for interaction between two groups of covariates.

Suggested references:

Chatterjee N., Kalaylioglu Z., Moslehi R., Peters U., Wacholder S. (2006). Powerful multilocus tests of genetic association in the presence of gene-gene and gene-environment interactions. American Journal of Human Genetics, Vol. 79, 1002-16.