[ Roster ]

TAG study section covers mechanisms by which genomic abnormalities that cause genetic disease lead to disease pathogenesis. Further, the study section covers development of therapeutics for genetic diseases.  Specific areas are:

• Molecular mechanisms of genetic disease pathogenesis at the level of: gene expression; epigenetic modifications; RNA metabolism; protein structure function; protein synthesis, post-translational modifications, folding and trafficking; metabolic and signaling pathways; regulatory networks.
• Development of genetic disease therapies: cellular and gene therapies; transfer, replacement and correction of genes; alterations of gene expression through silencing, modification or activation of gene expression; interventions (including small molecules) altering protein function, e.g., folding or post-translational modifications, enzyme replacement and substrate reduction therapies.
• Development of resources for mechanisms and therapies of genetic diseases:  stem cells, nucleic acid transfer vectors, and animal models of human diseases.
• Preclinical and initial clinical studies of genetic disease therapies

Study sections with most closely related areas of similar science listed in rank order are:

Genetics of Health and Disease [GHD] 
Gene and Drug Delivery [GDD]  
Molecular Neurogenetics [MNG]