Sol Spiegelman (1914-1983) was an American microbiologist who made several important contributions in the fields of microbial genetics and cancer research, particularly the discovery of RNA/DNA hybridization and the first synthesis of an infectious nucleic acid. From 1969 to 1983, he did innovative work on viruses that cause various cancers, developing new analytical techniques and increasing scientific understanding of retroviruses.

The Sol Spiegelman collection is available on NLM's Profiles in Science at http://profiles.nlm.nih.gov. Biographical material, correspondence, laboratory notebooks, published and unpublished writings, academic course material, subject files, memoranda, and illustrations document Sol Spiegelman's professional career as a microbiologist.