NIH’s National Children’s Study Enters Next Phase
Increase In Number of Centers Recruiting Volunteers,
The National Institutes of Health announced today that its comprehensive
study to examine the effect of genes and the environment on children’s
health had entered the next phase of operations. At a briefing
on the latest developments in the National Children’s Study, NIH
officials named the study centers funded for 2008.
The study centers are the research institutions that will recruit volunteers
for the study. Study centers will recruit from study locations
— counties and other geographic demarcations preselected by study scientists
to be representative of the United States.
The large size of the study requires that it be carried out in stages. Today,
NIH officials named the 27 study centers that will be funded in
2008, which will manage 39 locations. That brings the total of
new and existing study centers to 36, covering a total of 72 study
When it is fully operational, the study is expected to have approximately 40
study centers recruiting volunteers from the planned 105 study
locations throughout the United States.
The National Children’s Study will follow a representative national sample of
100,000 children from before birth to age 21. The study will investigate factors
influencing the development of such conditions as autism, cerebral palsy, learning
disabilities, birth defects, diabetes, asthma, and obesity.
"The advantage of a long term study of development is that it will yield important
health information at virtually every phase of the life cycle," said Elias A.
Zerhouni, M.D., director of the National Institutes of Health. "Eventually,
it will provide greater understanding of adult disorders. In the immediate future,
however, we expect it to provide insight into the disorders of birth and infancy."
At the briefing, NIH officials briefly recounted the history of the study. Authorized
by Congress in the Children’s Health Act of 2000, the National Children’s Study
is being conducted by a consortium of federal agencies. This includes two NIH
institutes, the Eunice Kennedy Shriver National Institute of Child Health and
Human Development and the National Institute of Environmental Health Sciences,
as well as the Centers for Disease Control and Prevention, and the U.S. Environmental
In 2004, study researchers announced the105 locations throughout the United States
from which study participants ultimately will be recruited by the study centers.
In 2005, the NIH awarded contracts for seven initial, or Vanguard, Centers, followed
by 17 additional centers in 2007.
The study centers will recruit participants, collect genetic, biological, and
environmental samples, and compile statistical information for study analyses
on the relationships between health, genetics, and the environment. The centers
consist of universities, hospitals, health departments, and private companies
or represent collaborations between these kinds of organizations. (A table of
the 2008 study centers and locations appears below.)
"The National Children’s Study will encompass a nationally representative sample,
designed to be a composite of the U.S. population, " said NICHD Director Duane
Alexander, M.D. "It will include children throughout the United States, from
rural, urban, and suburban areas, from all income and educational levels, and
from all racial groups."
Funding for the National Children’s Study is provided each year by Congress.
If funding is received as anticipated, and if the necessary technical approvals
are obtained, the National Children’s Study is expected to begin initial recruitment
at two of the Vanguard Centers in January 2009. This initial recruitment will
focus on pilot testing for the study—early phase testing of recruitment procedures
and sampling methods—before the full study begins. In April of 2009, the remaining
Vanguard Centers will join in enrollment for the pilot phase of the study. After
the pilot testing, the first wave of recruitment will begin in the summer of
Although the study can be expected to provide information throughout its duration,
information on disorders and conditions of early life are expected within the
next few years. Because the study will enroll pregnant women and, in some cases,
women who are not yet pregnant, study scientists hope to identify a range of
early life factors that influence later development.
"With more than 100,000 participants, we believe the National Children’s Study
will be the largest study of pregnant women ever conducted in the United States, " said
National Children’s Study Director Peter Scheidt, M.D., M.P.H. "We expect the
study to yield information on a variety of pregnancy and birth-associated conditions."
In particular, Dr. Scheidt added, the National Children’s Study could be expected
to provide information on the potential contributors to preterm birth. More than
500,000 preterm infants are born each year in the United States. Infants born
prematurely are at risk for early death and a variety of health problems, such
as cerebral palsy, mental retardation, and learning disabilities. Health care
costs for preterm infants total $26 billion per year.
"We expect that what we learn from the National Children’s Study will provide
new information that we can use to begin solving the problem of preterm birth, " Dr.
Scheidt said. “We are hopeful that we will have this information in just a few
Additional information about the National Children’s Study is available from
A chart of the 27 study centers funded for 2008 and their corresponding locations
appears at the following link: http://www.nichd.nih.gov/centers2008/.
The NICHD sponsors research on development, before and after birth; maternal,
child, and family health; reproductive biology and population issues; and medical
rehabilitation. For more information, visit the Institute’s Web site at http://www.nichd.nih.gov/.
The National Institutes of Health (NIH) — The Nation's
Medical Research Agency — includes 27 Institutes and
Centers and is a component of the U.S. Department of Health and
Human Services. It is the primary federal agency for conducting
and supporting basic, clinical and translational medical research,
and it investigates the causes, treatments, and cures for both
common and rare diseases. For more information about NIH and
its programs, visit www.nih.gov.