Ronald H. Schwartz, M.D., Ph.D., Chief
The Laboratory of Cellular and Molecular Immunology studies the development, activation, tolerance, memory, differentiation, and death of thymus-derived (T) lymphocytes. Research projects currently focus on lineage commitment in the thymus, the role of danger and costimulatory signals in initiating an immune response, the molecular basis of costimulation, molecular and cellular aspects of T-cell anergy, the cloning of genes from thymic epithelial cells, dissection of in vivo models of CD4+ T-cell tolerance, and the cloning of genes involved in T-cell receptor activation-induced cell death. The laboratory offers educational training in immunology through tutorials and weekly journal clubs in addition to research training in techniques such as flow cytometry, gene cloning, and T-cell cloning. All research is carried out using mouse models.
Office of the Chief
Ronald H. Schwartz, M.D., Ph.D.
T-Cell Activation Section
Ronald H. Schwartz, M.D., Ph.D.
T-Cell Biophysics Unit
Rajat Varma, Ph.D.
T-Cell Development Section
B.J. Fowlkes, Ph.D.
T-Cell Tolerance and Memory Section
Polly Matzinger, Ph.D.
Thymic Molecular Development Unit
Moon G. Kim, Ph.D.
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