In adults the best equation for estimating glomerular filtration rate (GFR) from serum creatinine is the Modification of Diet in Renal Disease (MDRD) Study equation.
Original MDRD Study Equation1,2
NOTE: This equation should be used only with those creatinine methods that have not been recalibrated to be traceable to IDMS. For more information about recalibration, visit NKDEP's Laboratory Professionals section.
GFR (mL/min/1.73 m2) = 186 x (Scr)-1.154 x (Age)-0.203 x (0.742 if female) x (1.212 if African-American) (conventional units)
The equation does not require weight because the results are reported normalized to 1.73 m2 body surface area, which is an accepted average adult surface area.
1 Levey AS, Greene T, Kusek J, and Beck G. A simplified equation to predict glomerular filtration rate from serum creatinine (abstract). J Am Soc Nephrol. 2000. 11: p.155A.
2 Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med. 1999 Mar 16;130(6):461–70.