National Institute on Drug Abuse
Director's Report to the National Advisory Council on Drug Abuse
September, 2000
Program Activities
New PAs/RFAs
NIDA PAs
On June 27, 2000 NIDA issued a Program Announcement entitled Molecular Genetics of Drug Addiction Vulnerability (PA-00-115). This PA seeks investigator-initiated applications for research projects that identify chromosomal loci and genetic variations in genes that are associated with increased vulnerability to addiction or dependence on stimulants (e.g., cocaine and amphetamine), narcotics (e.g., opiates), nicotine, benzodiazepines, barbiturates, cannabis, hallucinogens, and/or multiple drugs of abuse in human beings.
PAs With Other NIH Components
On June 15, NIDA, in conjunction with a number of other NIH Institutes, issued Program Announcements entitled Basic and Translational Research in Emotion (R01) (PA-00-105) and Basic and Translational Research in Emotion: Small Grants (PA-00-106). The purpose of these PAs is to invite research grant applications to expand basic research on the processes and mechanisms involved in the experience and expression of emotion.
On June 27, 2000, NIDA, in conjunction with the National Institute of Mental Health (NIMH) and the National Institute of Child Health and Human Development (NICHD), issued a Program Announcement entitled Developmental Psychopharmacology (PA-00-114) soliciting grant applications to study the possible clinically significant effects that various psychotropic medications may have on the brain when administered during the developing phase that spans from birth to early adulthood. The main goal is to generate data that are relevant to the clinical use of psychotherapeutic medications in children and adolescents with respect to safety and/or efficacy within dose ranges, schedules, and routes of administration that are usually employed therapeutically. The ultimate purpose is to increase our knowledge of the safety and effectiveness of psychopharmacological treatments administered to children and adolescents.
On June 29, 2000, NIDA, in conjunction with numerous other NIH components, issued Program Announcements entitled Innovations in Biomedical Information Science and Technology: Phased Innovation Award (R21/R33) (PA-00-117) and Innovations in Biomedical Information Science and Technology: SBIR/STTR Initiative (PA-00-118). Through these PAs participating Institutes and Centers of NIH invite applications for innovative research in biomedical information science and technology to promote the progress of biomedical research. There exists an expanding opportunity to speed the progress of biomedical research through the power of computing to manage and analyze data and to model biological processes. The NIH is interested in promoting research and developments in biomedical information science and technology that will support rapid progress in areas of scientific opportunity in biomedical research.
On June 29, 2000, NIDA, in conjunction with numerous other NIH components, issued a Program Announcement entitled Planning Grants: National Program of Excellence in Biomedical Computing (PRE-NPEBC) (PAR-00-102). Through this announcement participating components of the NIH invite applications for P20 planning grants that lead to the establishment of National Programs of Excellence in Biomedical Computing. Subsequent to this PA, a series of solicitations will be issued by participating NIH Institutes and Centers to invite applications for National Programs of Excellence in Biomedical Computing (NPEBC) awards.
On July 25, 2000, NIDA, in conjunction with several other NIH Institutes, issued a Program Announcement entitled National Research Service Awards for Individual Predoctoral Fellows (PA-00-125). This is a revision and expansion of PA-99-017 that was published in the NIH Guide on November 19, 1998 and will remain active for three years. This program will provide predoctoral training support for doctoral candidates that have successfully completed their comprehensive examinations or the equivalent by the time of award and will be performing dissertation research and training.
RFAs With Other NIH Components
On May 24, 2000, NIDA and the National Institute of Mental Health (NIMH) issued an RFA entitled Research on Depression Comorbid With Externalizing Problems in Children (MH-01-002). The purpose of this RFA is to solicit research grant award applications for research on early identification of depression (Dysthymic Disorder and/or Major Depressive Disorder) comorbid with disruptive behavior problems or disorders (persistent antisocial behavior, attention deficit hyperactivity disorder, oppositional-defiant disorder, and conduct disorder) in children under 12 years of age in pre-school, school, pediatric care, and other settings - and for intervention research designed to treat or prevent these comorbid conditions.
Other Program Activities
Transdisciplinary Tobacco Use Research Centers Update
On June 14, 2000, Dr. Jaylan Turkkan reported to the National Cancer Institute (NCI) National Advisory Board (NCAB) on NIDA's support and activities in nicotine and tobacco use research, including the creation of and progress on the Transdisciplinary Tobacco Use Research Centers (TTURC). On June 29 and 30, 2000 the TTURC Principal Investigators, co-investigators, Mr. Richard Millstein, NIDA Deputy Director and other NIDA staff, NCI staff, staff of the Robert Wood Johnson Foundation and members of the newly appointed Consultation Committee to the TTURCs met for their second retreat, held in Alexandria, Virginia. Consultation Committee Members for the TTURC are: Gary E Swan, Ph.D., SRI International; John "Kim" Worden, Ph.D., University of Vermont; Kathleen T. Brady, M.D., Ph.D., Medical University of South Carolina; Ellen R. Gritz, Ph.D., UT M.D. Anderson Cancer Center; Denis J. Prager, Ph.D., Strategic Consulting Services; Richard R. Clayton, Ph.D., University of Kentucky; Tom Glynn, Ph.D., American Cancer Society; and Michael Goldstein, M.D., Bayer Institute for Communication. The TTURC investigators discussed the potential for cross-center collaborative projects in genetics, cultural research, neuroimaging, cost-effectiveness, and policy-related research in tobacco use. A third retreat is scheduled in San Diego, CA for late January 2001.
The Methamphetamine Clinical Program
To implement the recommendations of the Methamphetamine Addiction Treatment Think Tank (MATTT) meeting held in January 2000, a process was started to establish a group of sites to conduct clinical trials for methamphetamine dependent patients. Five sites have been selected where the epidemic is currently concentrated, two in the Midwest (Des Moines, Iowa, and Kansas City, Kansas), and the other three are Los Angeles, San Diego, CA, and Honolulu, HI. The first medication study protocol is finalized (bupropion) and was sent to local IRBs for review. This study is projected to start in October 2000. Additionally, selegiline will be studied first in inpatient clinical pharmacology studies at UCLA and UCSF for safety interactions with amphetamine. Following these studies, and if safety is not an issue, selegiline will be advanced to outpatient studies following completion of the bupropion study. Plans are underway to obtain lobeline from a pharmaceutical manufacturer to study its safety profile with amphetamine and ultimately also advance it to outpatient studies.
Clinical Research Efficacy Screening Trial (CREST-I) Study
On April 26, 2000 a group of outside consultants reviewed the data from each NIDA/VA Medications Development Research Unit (MDRU) in their CREST studies (three medications each and an unmatched placebo). Out of the 15 medications reviewed three medications were shown to give positive signals in these screening pilot studies. Reserpine (an antihypertensive medication) gave the strongest signal while cabergoline (dopamine agonist) and hydergiene (a brain metabolic and blood flow enhancer) gave weak signals. The recommendations of the consultants were to follow up with larger phase II studies on these medications.
Clinical Research Efficacy Screening Trial (CREST-II) Study
Similar to CREST-I, the second phase of rapid drug screening started following the completion of CREST-I. This second round involves eight different medications. The estimated completion time for these studies is November 2000. The data from these trials will be analyzed and reviewed by consultants by January/February 2001.
Cocaine Clinical Trials Operations
This network of four academic clinical sites has been established to replace the old MDRU sites to conduct clinical trials for cocaine addiction. These are UCLA, University of Cincinnati, Medical University of South Carolina, and University of Texas at San Antonio. The contract is in place with two other supporting contracts with TRI and KAI for data management. Eight protocols have been submitted for the sites to study, three are phase one interaction studies (Modafnil, Metyrapone, Tolcapone) one phase IIa study (Ondansteron) and two phase IIb studies (resperpine and cabergoline). These studies are projected to start in October 2000.
GBR 12909
The report from the Phase I (healthy volunteer) study is complete and will be reviewed by consultants in September 2000 in planning for a cocaine interaction study. The study showed 30-40% dopamine transporter occupancy at the 100mg dose level. Based on primate data showing equivalent levels of occupancy at doses reducing cocaine self-administration, this may be clinically meaningful in cocaine treatment.
NS2359
The final protocol for this safety cocaine interactions study has been submitted to FDA for review and is on line to start in January 2001.
Methylphenidate in Cocaine Dependant Individuals with Attention Deficit Disorder
An open label feasibility study showed a promising effect of methylphenidate in decreasing cocaine use in this co-morbid subgroup. NIDA has awarded a grant for Dr. Frances Levin to further study methylphenidate in this subgroup in a large double blind study. This study is approximately half way through completion.
Selegiline
The selegiline IR study has been completed and data are currently being analyzed. The VA Cooperative Studies Program review committee and their central IRB have approved the phase III 300 subject Selegiline Transdermal System study protocol. The protocol was sent out to local investigators for review by local IRBs and was also submitted to FDA for review. This study is projected to start by November 2000.
Lofexidine for Heroin Withdrawal Study
This phase III multisite study protocol was recently reviewed and approved by the VACSP central IRB, and will be reviewed by the VA CSP review committee. Following this review the protocol will be reviewed by the local sites IRBs as well as the FDA. Projected date to start this study is January 2000.
Desipramine in Cocaine Dependence
The Clinical/Medical Branch will follow the collective opinion of consultants that NIDA should further evaluate the concept of a desipramine therapeutic window in a phase II study. The protocol is near completion and will be submitted through the Clinical Trials Operations contract mechanism. Projected start date is March 2001.
Indian Health Research Centers
NIDA has agreed to fund substance abuse related projects that are approved through an RFA to establish Indian Health Research Centers issued through the Indian Health Service and NIGMS. Support for this initiative was recommended by the Native American/Alaska Native Work Group convened by the Special Populations Office. Kathy Etz, DESPR, Arnold Mills, DESPR, Richard Harrison, OEA and Lula Beatty, SPO, are NIDA staff who are working on the implementation of this activity.
National Hispanic Science Network on Drug Abuse
The Special Populations Office released an RFC to develop a National Hispanic Science Network on Drug Abuse in June 2000. Award of the contract is expected to be made by November 2000.
Summer Research with NIDA
For the fourth consecutive year, the Special Populations Office sponsored the Summer Research with NIDA program. Through placements with NIDA extramural investigators, 32 minority high school and undergraduate students were able to gain valuable research experience.
NIH Summer Internship Program
Scientists at the NIDA IRP selected 11 students to participate in the NIH Summer Internship Program (high school through graduate school). Students spent 8-10 weeks at NIDA working with scientists on various research projects and attending seminars at NIDA and NIH. The internship culminated in the NIH Student Poster Day held at the Clinical Center in Bethesda on August 3, 2000, where more than 300 students presented their research findings. Dr. Stephen Heishman is the NIDA coordinator of the NIH program.
NIDA's New and Competing Awards Since April 2000
Abrams, David B. --- Miriam Hospital
Nicotine Dependence: Risk & Recovery Over Generations
Al'absi, Mustafa N. --- University of Minnesota
Nicotine Withdrawal & Responses To Psychological Stress
Amass, Leslie --- Friends Research Institute, Inc.
Contingency Management for Real-Life Drug Treatment
Ananthan, Subramaniam --- Southern Research Institute
Novel Nonpeptide Ligands for the Opioid Receptors
Anglin, M. Douglas --- University of California, Los Angeles
Drug Abuse Treatment: Process, Outcomes, & Social Policy
Atkinson, J. Hampton --- University of California
Better Antiretroviral Adherence: HIV+ Amphetamine Users
Barker, Eric L. --- Purdue University
Molecular Analysis of Endogenous Cannabinoid Transport
Battaglia, George --- Loyola University Chicago
SSRI Treatment of Prenatal Cocaine-Induced 5HT Deficits
Beauvais, Frederick --- Colorado State University
Drug Use Among Young Indians: Epidemiology & Prediction
Bickel, Warren K. --- University of Vermont
Improving Combined Buprenorphine-Behavioral Treatment
Billy, John O. --- Battelle Centers Public Health
Contextual Effects On Adolescent Drug Involvement
Booth, Robert E. --- University of Colorado
Intervention To Reduce Injection Drug Use
Booze, Rosemarie M. --- University of Kentucky Medical Center
HIV/Cocaine Neurotoxicity In Females
Cadoret, Remi J. --- University of Iowa College of Medicine
Gene-Environment Interaction In Etiology of Drug Abuse
Caldwell, Linda L. --- Pennsylvania State University
Leisure Education Prevention Program for Junior High
Campbell, William B. --- Medical College of Wisconsin
Biochemistry of Anandamide, An Endogenous Cannabinoid
Catalano, Richard F. --- University of Washington
Etiology of Substance Use In Australia/USA
Caton, Carol L. --- NY York State Psychiatric Institute
Service Needs In Early Psychosis and Drug Use
Cepeda-Benito, Antonio --- Texas A & M University
Nicotine Tolerance: Associative and Nonassociative
Chelonis, John J. --- University of Arkansas
Effects of Prenatal Cocaine On Behavioral Plasticity
Cherek, Don R. --- University of Texas Health Sciences Center at Houston
Drugs of Abuse and Human Aggressive Behavior
Chitwood, Dale D. --- Research & Sponsored Program
Intervention Among Heroin Sniffers-Prevent IV Drug Use
Coussons-Read, Mary E. --- University of Colorado
Effects of Morphine on Pulmonary Influenza Infection
Covey, Lirio S. --- New York State Psychiatric Institute
Maintenance Treatment for Prevention of Smoking Relapse
Cunningham, Kathryn A. --- University of Texas Medical Branch
Neurobehavioral Pharmacology of Stimulants
Cunningham-Williams, Renee M. --- Washington University
Issues In Gambling and Comorbid Drug Abuse
Dansereau, Donald F. --- Texas Christian University
Cognitive Enhancements for Treatment of Probationers
Dobs, Adrian S., MD --- Johns Hopkins University
Gonadal Hormones on Body Composition, HIV and Drug Use
Dovovan, Stephen J. --- Columbia University of the Health Sciences
Pharmacology of Addiction Risk Factors
Duncan, Terry E. --- Oregon Research Institute
Social Context and Adolescent Substance Use Development
Edwards, Robert H. --- University of California, San Francisco
Presynaptic Mechanisms of Neural Plasticity
Ellickson, Phyllis L. --- RAND
Consequences of Prior Drug Use for Young Adults
Ennett, Susan T. --- University of North Carolina at Chapel Hill
The Context of Adolescent Substance Use
Erickson, Carlton K. --- University of Texas at Austin
Drug Abuse Education for Professionals
Fleckenstein, Annette E. Ph.D. --- University of Utah
Drug Abuse and Regulatory Enzymes of Biogenic Amines
Foltin, Richard W. --- New York State Psychiatric Institute
Anorectic Drugs: Abuse & Behavioral Mechanisms of Action
Foltin, Richard W. --- Research Foundation for Mental Hygiene
Cocaine's Effects Across the Menstrual Cycle
Friedman, Alfred S. --- Belmont Center for Comp Treatment
Effects of Drug Abuse on Young Black Adult Functioning
Friedman, Samuel --- National Development & Research Institute, Inc.
Networks, Norms and HIV/STI Risk Among Youth
Friedman, Samuel --- National Development & Research Institute, Inc.
Community Vulnerability and Responses to IDU-Related HIV
Gelernter, Joel E. --- Yale University School of Medicine
Genetics of Opioid Dependence
Gibb, James W. --- University of Utah
Neurochemical Alterations By Designer Drugs
Gnegy, Margaret E. --- University of Michigan Medical School
Pharmacology of Dopamine Release By Amphetamine
Gomez, Felipe, Ph.D. --- University of Michigan
Conditioned Corticosterone and Drugs of Abuse
Green, Alan I. --- Massachusetts Mental Health Center
Cannibus and Schizophrenia: Clozapine Vs Risperidone
Greene, Ross W. --- Massachusetts General Hospital
Prevention of Substance Abuse In High-Risk ADHD Children
Grigson, Patricia S. --- Pennsylvania State University
Drugs of Abuse, Reward Comparison, and the Thalamus
Gruen, Rand J. --- New York University Medical Center
Amphetamine, GABA Transmission, and Behavior
Halpern, John H. --- McLean Hospital
Cognitive Effects of Substance Use In Native Americans
Haney, Margaret --- New York State Psychiatric Institute
THC and Marijuana: Effects In Individuals With HIV/AIDS
Hauser, Kurt F. --- University of Kentucky Medical Center
Opioids and Central Nervous System Vulnerability To HIV
Helstrom, Amy W. --- University of Colorado, Boulder
A Smoking Intervention For Juvenile Offenders
Henriksen, Steven J. --- Scripps Research Institute
Methamphetamine and AIDS: Toxic Interactions In Animals
Hienz, Robert D. --- Johns Hopkins University
Effects of Abused Drugs on Perception: An Animal Model
Hienz, Robert D. --- Johns Hopkins University
Drug Dependence and HIV/AIDS: A New Biobehavioral Model
Hiroi, Noboru --- Albert Einstein College of Medicine
Intracellular Molecules of Nicotine Addiction
Hone, Robert W. --- Red Hill Studios
The Science of Drugs
Hough, Lindsay B. --- Albany Medical College
Histaminergic Mechanisms of Antinociception
Howlett, Allyn C. --- University of Vermont
ICRS Symposium on the Cannabinoids
Hruby, Victor J. --- University of Arizona, Tucson
Novel Non-Peptide Opioid Ligands for Pain
Hughes, John R. --- University of Vermont
Nicotine Dependence & Tobacco Use Research
Hurwitz, Barry E. --- University of Miami
Drug Abuse, HIV, Selenium Supplementation, and CVD Risk
Iacono, William G. --- University of Minnesota, Minneapolis
Twin Study of ADHD, CD, and Substance Abuse
Jansson, Lauren M. --- Johns Hopkins University
Methadone, Buprenorphine and Fetal Development
Johns, Josephine M. --- University of North Carolina at Chapel Hill
Cocaine and Maternal Neglect: Intergenerational Effects
Kadden, Ronald M. --- University of Connecticut Health Center
Contingency Management for Marijuana Dependence
Kalivas, Peter W. --- Medical University of South Carolina
Cocaine Opioids and Drug Abuse
Kandel, Denise B. --- Columbia University
Nicotine Dependence Among US Youths
Kauer, Julie A. --- Office of Research Administration
Glutamate Synapses In Sensitization to Drugs of Abuse
Kellam, Sheppard G. --- Society for Prevention Research
Society For Prevention Research Annual Conference
Knowles, James A. --- New York State Psychiatric Institute
Genetic Risk Factors for Nicotine Addiction
Kosten, Thomas R. --- American Academy of Addiction Psychiatry
11th - 15th Annual Meetings and Symposia
Kozikowski, Alan P. --- Georgetown University Medical School
Chemical and Pharmacological Studies of Cocaine Analogs
Kuhn, Donald M. --- Wayne State University School of Medicine
Neurotoxic Amphetamines Radical & 5HT Neurons
Lama, Juan, Ph.D. --- La Jolla Institute for Allergy/Immunology
Role of CD4 Downmodulation During HIV Infection
Lane, Scott D. --- University of Texas Health Sciences Center at Houston
Marijuana Effects On Basic Behavioral Mechanisms
Lang, Annie --- Indiana University
Processing PSAs: Production Pacing, Emotion, and Arousal
Lappi, Douglas A. --- Advanced Targeting Systems
A Tool to Study the Diverse Behavioral Effects of Galanin
Latkin, Carl A. --- Johns Hopkins University
The Long-Term Impact of A Network Outreach Intervention
Lau, Chyan E. --- Rutgers University
Stimulant Abuse Behavior and Pharmacokinetics
Levin, Frances R. --- Columbia University Health Sciences Division
Treatment of Substance Abuse and Psychiatric Comorbidity
Liddle, Howard A. --- University of Miami
Adolescent Susbtance Abuse Treatment Conference
Lipton, Jack W. --- Rush-Presbyterian-St. Luke's Medical Center
Oxidant Stress and Cocaine-Induced Brain Injury In Utero
Lundy, Allan C. --- Thomas Jefferson University
Accuracy of ASI Reports of Cocaine Use at Follow-Up
Mach, Robert H. --- Wake Forest University School of Medicine
Development of D3 Antagonists To Treat Cocaine Addiction
Mackinnon, David P. --- Arizona State University
Analysis of Team-Based Substance Abuse Prevention
Madden, Pamela A. --- Washington University
The Genetics of Vulnerability to Nicotine Addiction
Magura, Stephen Ph.D. --- National Development & Research Institute, Inc.
Group Motivational Intervention In Drug Abuse Treatment
Makris, Angela --- University of Kentucky College of Medicine
The Effects of Modafinil on Food Intake In Humans
Marcus, Marsha D., Ph.D. --- Western Psychiatric Institute & Clinic
Bupropion and Weight Control for Smoking Cessation
Markham, Richard B. --- Johns Hopkins University
Drug Abuse and Resistance to Antiretroviral Therapy
Markou, Athina --- Scripps Research Institute
Neurobiology of Nicotine Reward and Withdrawal
Marvizon, Juan-Carlos G. --- University of California, Los Angeles
Spinal Neurokinin and Opioid Release In Nociception
Matsumoto, Rae R. --- University of Oklahoma Health Sciences Center
Sigma Ligands for the Treatment of Cocaine Overdose
Mazure, Carolyn M. --- Yale University
Yale IWHR Scholar Program On Women and Drug Abuse
Mccarson, Kenneth E. --- University of Kansas Medical Center
Nociceptive Sensory Regulation of Neurokinin Receptors
Mcfarland, Bentson --- Oregon Health Sciences University
Drug Courts and Medicaid Managed Behavioral Health Care
Meisch, Richard A., MD --- University of Texas Health Sciences Center
Polydrug Abuse: Reinforcing Effects of Drug Combinations
Moore, Steven D. --- Center for Image Processing In Education
Visualizing Addiction: Imaging for Secondary Science Education
Morrissey, Joseph P. --- University of North Carolina at Chapel Hill
Impacts of Managed Care on Substance Abuse Service Linkages
Musto, David F., MD --- Yale University
Previous American Drug Experience & Future Perspectives
Nader, Michael A. --- Wake Forest University School of Medicine
Dopamine D2 Receptors In Primate Models of Cocaine Abuse
Napier, T. Celeste, Ph.D. --- Loyola University
Opioids and the Physiology of the Ventral Pallidum
Nestler, Eric J. --- University of Texas Southwestern Medical Center
Neurotrophic Factors and Drugs of Abuse
Nunes, Edward V. --- Research Foundation for Mental Hygiene
Opiate Dependence: Combined Naltrexone/Behavior Therapy
Oetting, Eugene R. --- Senior Research Administrator, Sponsored Programs
The Tri-Ethnic Center For Prevention Research
Page, J. B. --- University of Miami
HIV Infection Potential /IDU-Related Injection Materials
Perkins, Kenneth A. --- University of Pittsburgh
Sex Differences In Nicotine Reinforcement: Human/Animal
Petry, Nancy M. --- University of Connecticut Health Center
Vouchers Vs. Prizes: Contingency Management
Polich, John M. --- The Scripps Research Institute
Marijuana CNS Effects In Low- And High Risk--Supplement
Rajadhyaksha, Anjali M. --- Massachusetts General Hospital
Amphetamine-Mediated Phosphorylation and Gene Expression
Reggio, Patrici H. --- Kennesaw State University
Molecular Determinants for Cannabinoid Activity
Reith, Maarten E. --- University of Illinois College of Medicine
Dopamine Transporters and Ions, Substrates, Blockers
Ridenour, Ty A. --- Washington University
Drug Use Liability: Investigating Competing Models
Robles, Rafaela R. --- Universidad Central Del Caribe
Puerto Rico Drug Abuse Research Development Program
Robles-Sotelo, Elias --- University of Arkansas
Delay Discounting & Impulsiveness In Methadone Patients
Roddy, Juliette K. --- Office of Research & Sponsored Programs
An Economic Analysis of Cigarette Smoking
Ruth, James A. --- University of Colorado Health Sciences Center
Mechanisms of Drug Deposition In Hair
Salvemini, Daniela --- Metaphore Pharmaceuticals, Inc.
Superoxide Dismutase Mimetics for Management of Pain
Santisteban, Daniel --- University of Miami
Developing A Culturally Rooted Adolescent Family Therapy
Sherman, Steven J. --- Indiana University
Social Psychological Factors In Teen and Adult Smoking
Simon, Eric J. --- New York University School of Medicine
31st Annual International Narcotics Research Conference
Smith, Mark --- Davidson College
Age-Related Differences In Opioid Sensitivity
Smith, Miles P. --- Zebra Pharmaceuticals, Inc.
Polypharmacophore Model for Treatment of Cocaine Abuse
Snyder, Solomon H. --- Johns Hopkins University School of Medicine
Neurotransmitter Receptors
Sparber, Sheldon B. --- University of Minnesota
Prenatal Cocaine-Acute & Delayed Functional Toxicity
Spielberg, Freya --- Harborview Medical Center
Counseling Strategies to Reduce HIV Risk Among IDU
Stephan, Megan M. --- Yale University School of Medicine
Functions of Membrane Spans In the Serotonin Transporter
Stewart, David G. --- Children's Hospital & Regional Medical Center
Ready: School-Based Substance Abuse Intervention
Strauss, Shiela M. --- National Development & Research Institute, Inc.
HVC Service Innovations In Drug Treatment Programs
Tallarida, Ronald J. --- Temple University School of Medicine
Synergism and Medications Development for Drug Abuse
Taylor, Ethan W. --- University of Georgia
Selenoproteins, Nf-Kb, And HIV Disease In IV Drug Users
Todorovic, Slobodan M. --- Washington University
Multiple Classes Of Ca2+ Channels - Sensory Transmission
Toll, Lawrence R. --- SRI International
Biochemical Studies of Opiate Efficacies
Tompkins, Christopher --- Brandeis University
Development of Case Rates For Substance Abusers
Trussell, Laurence O., Ph.D. --- OHRC & Vollum Institute
Gordon Conference on Synaptic Transmission
Tsoh, Janice Y. --- University of California, San Francisco
Treating Chinese Smokers With Interactive Expert Systems
Van Haaren, Frans --- University of Florida
Impulsivity: Precursor to and Sequel of Toxicant Exposure
Vaughan, Mary S. --- University of Iowa
Gender Differences In Health Services Utilization
Vlahov, David --- New York Academy of Medicine
Evaluating Supervised HAART In Late Stage HIV In IDUs
Waldron, Holly B. --- University of New Mexico
Drug Use & HIV Risk: Treatment of Hispanic & Anglo Youth
Webster-Stratton, Carolyn H. --- University of Washington
Preventing Conduct Problems, Promoting Social Competence
Weiss, Friedbert --- Scripps Research Institute
Novel Methods to Explore Mechanisms of Cocaine Abuse
Wessendorf, Martin W. --- University of Minnesota, Minneapolis
Brainstem Circuits In Opiate Analgesia
Williams, John T. --- Oregon Health Sciences University
Cocaine: Effects on Single Neurons
Wolf, Marina E. --- Chicago Medical School
Glutamate Transmission and Amphetamine Sensitization
Worley, Paul F. --- Johns Hopkins University School of Medicine
Analysis of A Novel Cocaine-Induced IEG
Wu, Li T. --- Research Triangle Institute
Substance Use & Dependence Problems Among the Uninsured
Xian, Hong --- Washington University
Smoking Cessation: The Role of Withdrawal & Dependence
Yamamoto, Bryan K. --- Case Western Reserve University
Methamphetamine Toxicity and Corticostriatal Glutamate
Yantis, Steven G. --- Johns Hopkins University
Brain Mechanisms of Attentional Control Revealed By fMRI
Zhang, Heping --- Yale University School of Medicine
Statistical Methods for Correlated Substance Use Data
[ Office
of the Director][Report Index][Next
Report Section]
|
