Biography

Dr. Goldin received a Ph.D. in genetics from the University of North Carolina at Chapel Hill in 1978. She was a researcher in the Clinical Neurogenetics Branch of the National Institute of Mental Health and joined the NCI Genetic Epidemiology Branch in 1998. Dr. Goldin's major research interests are in developing and evaluating statistical methods and study designs for detecting susceptibility genes for complex diseases, quantifying familial aggregation of disease, and applying these methods to familial cancer studies.

Research Interests

• Gene detection in families at high risk for lymphoproliferative tumors
• Statistical methods for genetic analyses
• Familial aggregation of hematologic malignancies and precursor conditions using Nordic registries

Keywords

linkage studies, association studies, gene mapping, candidate genes, familial aggregation, hematologic malignancies

Selected Publications

• Goldin LR, Slager SL. Familial CLL: Genes and environment. Hematology Am Soc Hematol Educ Program 2007;339-45.
• Sellick GS, Goldin LR, Wild RW, Slager SL, Rassenti L, Strom SS, Dyer MJS, Mauro FR, Marti FE, Fuller S, Lyttelton M, Kipps T, Keating MJ, Call TG, Catovsky D, Caporaso N, Houlston RS. A high-density SNP genome-wide linkage search of 206 families identifies susceptibility loci for chronic lymphocytic leukemia. Blood 2007;110:3326-3333.
• McMaster ML, Goldin LR, Bai Y, Ter-Minassian M, Boehringer S, Giambarresi TR, Vasquez LG, Tucker MA. Genome-wide linkage screen for Waldenström macroglobulinemia susceptibility loci in high-risk families. Am J Hum Genet 2006;79:695-701
• Landgren O, Engels EA, Pfeiffer RM, Gridley G, Mellemkjaer L, Olsen JH, Kerstann KF, Wheeler W, Hemminki K, Linet MS, Goldin LR. Autoimmunity and susceptibility to Hodgkin lymphoma: A population-based case-control study in Scandinavia. JNCI 2006;98(18:1321-30.
• Ng D, Marti GE, Fontaine L, Toro JR, Caporaso N, Goldin LR. High density mapping and follow-up studies on chromosomal regions 1,3,6,12,13 and 17 in 28 families with chronic lymphocytic leukaemia. Br. J Haematol. 2006;133:59-61.
• Landgren O, Linet MS, McMaster ML, Gridley G, Hemminki K, Goldin LR. Familial characteristics of autoimmune and hematologic disorders in 8,406 multiple myeloma patients: A population-based case-control study. Int J Cancer. 2006;118:3095-8.
• Goldin LR, Landgren O, McMaster ML, Gridley G, Hemminki K, Li X, Mellemkjaer L, Olsen JH, Linet M. Familial aggregation and heterogeneity of non-Hodgkin lymphoma in population-based samples. Cancer Epidemiol Biomarkers Prev 2005;10:2402-6.
• Goldin LR, McMaster ML, Ter-Minassian M, Saddlemire S, Harmsen B, Lalonde G, Tucker MA. A genome screen of families at high risk for Hodgkin lymphoma: Evidence for a susceptibility gene on chromosome 4. J Med Genet 2005;42:595-601.
• Goldin LR, Pfeiffer RM, Li X, Hemminki K. Familial risk of lymphoproliferative tumors in families of patients with chronic lymphocytic leukemia: Results from the Swedish Family-Cancer Database. Blood 2004;104(6):1850-4.
• Pfeiffer RM, Goldin LR, Chatterjee N, Daugherty S, Hemminki K, Pee D, Li X, Gail MH. Methods for testing familial aggregation of diseases in population based samples: application to Hodgkin lymphoma in Swedish registry data. Ann Hum Genet 2004; 68:498-508.