Simmonds, A.C, Reilly, C. A, Baldwin, R M., Ghanayem, B. I., Lanz, D L., Yost, G.S., Collins, K S., and Forkert, P-K. Bioactivation of 1,1-Dichloroethylene by CYP2E1 and CYP2F enzymes. Drug Metab. Disp. 32:1032-1039, 2004. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15319346)
Simmonds, A.C, Ghanayem, B.I., Sharma, A., Reilly, C.A., Brandie, M., Yost, G.S., and Forkert, P-K: Bioactivation of 1,1-Dichloroethylene by CYP2E1 and CYP2F2 in Murine Lung. J Pharmacol. Exp. Therap. 310:855-864, 2004. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15123768)
Blaisdell, J., Mohrenweiser, H., Coulter, S., Ferguson, S.S., Chanas, B., Xi, T., Ghanayem, B. I., and Goldstein, J.A. Discovery of new potentially defective alleles on human CYP2C9. Pharmacogenetics 14:527-537, 2004. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15284535)
El-Hadri L, Chanas B, and Ghanayem, B.I. Comparative metabolism of methacrylonitrile and acrylonitrile to cyanide using CYP2E1- and microsomal epoxide hydrolase- (mEH) null mice. Toxicol. Appl. Pharmacol. 205:116-125, 2005. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15893539)
Hoffler U., Dixon D., Pedadda S., and Ghanayem B.I.: Inhibition of Urethane-Induced Genotoxicity and Cell Proliferation in CYP2E1-null Mice. Mutation Research: Fund. Molec. Mech. Mutag. 572:58:72, 2005. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15790490)
Hoffler U. and Ghanayem B.I.: Increased Bioaccumulation Urethane in CYP2E1-/- Versus wild-type mice. Drug Metab. Disp. 33:1144:1150, 2005. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15879495)
Ghanayem, B.I., Witt, K.L., El-Hadri, L., Hoffler, U., Kissling, G.E., Shelby, M.D., Bishop, J.B.: Comparison of germ cell mutagenicity in male CYP2E1-null and wild-type mice treated with acrylamide: evidence supporting a glycidamide-mediated mechanism. Biol. Reprod. 72:157-163, 2005. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15355880)
Ghanayem, B.I., McDaniel, P.L., Churchwell, M. I. Twaddle, N. C., Snyder, R., Timothy R Fennell T R., and Daniel R. Doerge D R. Role of CYP2E1 in the epoxidation of acrylamide to glycidamide and formation of DNA and hemoglobin adducts. Tox. Sci. 88:311-318, 2005. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16141435)
Ghanayem B.I., Witt KL, Kissling GE, Tice RR, Recio L. Absence of acrylamide-induced genotoxicity in CYP2E1-null mice. Mutation Research: Fund. Molec. Mech. Mutag. 578:284-297, 2005. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15982677)
Lee, Su-Jen, Bell, D. A., Coulter, S.J., Ghanayem, B.I., and Goldstein, J.A. Recombinant CYP3A4*17 is defective in metabolizing the hypertensive drug nifidepine, and the CYP3A4*17 allele may occur on the same chromosome as CYP3A5*3, representing a new putative defective CYP3A halotype. J. Pharmacol. Exp. Therap. 313:302:309, 2005. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15634941)
Forkert, P-K, Millen, B., Lash, L H., Putt, D. A., and Ghanayem, B.I. Pulmonary Bronchiolar Cytotoxicity and Formation of Dichloroacetyl Lysine Protein Adducts in Mice Treated with Trichloroethylene. J Pharmcol. Exp. Therap. 316:520-529, 2006. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16269531)
Kim, D. and Ghanayem, B.I. Comparative metabolism and disposition of trichloroethylene in Cyp2e1-/- and Wild-Type Mice. Drug Metabolism and Disposition 34:2020-2027, 2006. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16959879)
Ghanayem, B.I. Inhibition of Urethane-Induced Carcinogenicity in Cyp2e1-/- in Comparison to Cyp2e1+/+ Mice. Toxicol. Sci. 95:331-339, 2007. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17093202)
Garner, C, Sloan, C, Burgess, J, Davis, J, Etheridge A, Parham, A. and Ghanayem B.I. CYP2E1-Mediated Oxidation Contributes to the Metabolism and Sperm Toxicity of 1-Bromopropane in Mice. Biol. Repr. 76:496-505, 2007. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17093198)
Ghanayem BI, Hoffler U. Investigation of xenobiotics metabolism, genotoxicity, and carcinogenicity Using Cyp2e1-/- mice. Current drug metabolism 8(7):728-749, 2007. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17979661)
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