Nominations to the Testing Program

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The NTP maintains a balanced research and testing program that provides data addressing a wide variety of issues important to public health. The NTP actively seeks to identify and select for study chemicals and other substances for which sufficient information is not available to adequately evaluate potential human health hazards. The NTP accomplishes this goal through a formal open nomination and selection process. Substances considered appropriate for study generally fall into two broad yet overlapping categories:

  1. Substances judged to have high concern as a possible public health hazard based on the extent of human exposure and/or suspicion of toxicity.
  2. Substances for which toxicological data gaps exist and additional studies would aid in assessing potential human health risks, e.g. by facilitating cross-species extrapolation or evaluating dose-response relationships.

Input is also solicited regarding the nomination of studies that permit the testing of hypotheses to enhance the predictive ability of future NTP studies, address mechanisms of toxicity, or fill significant gaps in the knowledge of the toxicity of classes of chemical, biological, or physical substances. Increased efforts continue to be focused on:

  1. Improving the quality of the nominations of chemicals, environmental agents, or issues for study so that public health and regulatory needs are addressed.
  2. Broadening the base and diversity of nominating organizations and individuals.
  3. Increasing nominations for studying toxicological endpoints in addition to carcinogenesis.