Nominations to the Testing Program
Nominations in Review 2007
-
Aminopyridines
- 2-Aminopyridine
- 3-Aminopyridine
- 4-Aminopyridine
-
Artificial butter flavoring mixture and certain components
- Acetoin
- Diacetyl
- Asbestos, naturally occurring and atypical forms
- Diethyl phthalate
- 2',2'''-Dithiobisbenzanilide
- 2-Methoxy-4-nitroaniline
-
Nanoscale materials
- Nanoscale gold
- Nanoscale silver
- o-Phthalaldehyde
Substances for Which No Study is Recommended at this Time:
* Note: A recommendation for "toxicological characterization" in this table includes studies for genotoxicity, subchronic toxicity, and chronic toxicity/carcinogenicity, as determined to be appropriate during the conceptualization and design of a research program to address toxicological data needs. Though other types of studies (e.g. metabolism and disposition, immunotoxicity, reproductive/developmental toxicity) may be conducted as part of a complete toxicological characterization, these types of studies are not listed unless they were specifically recommended. Preliminary study recommendations are developed and refined by the nominator, NTP staff, and the ICCEC.
For information, questions or comments, contact:
Dr. Scott A. Masten
Director, Office of Nomination and Selection
Environmental Toxicology Program
National Institute of Environmental Health Sciences
Research Triangle Park, NC
(919) 541-5710 (voice)
(919) 541-3647 (fax)
[ Send Email ]
Substance |
Nominated by |
Nomination Rationale |
Preliminary Study Recommendations |
---|---|---|---|
Aminopyridines:
|
National Cancer Institute | Moderate production and use; acutely toxic; lack of adequate toxicological data; suspicion of toxicity and carcinogenicity based on structure (1, 3, 6, 7) |
|
Substance |
Nominated by |
Nomination Rationale |
Preliminary Study Recommendations |
---|---|---|---|
Artificial butter flavoring mixture and certain components:
|
United Food and Commercial Workers International Union | Evidence of lung disease in exposed workers and respiratory toxicity in short-term animal toxicity studies (1, 5, 7) |
|
Substance |
Nominated by |
Nomination Rationale |
Preliminary Study Recommendations |
---|---|---|---|
Asbestos, naturally occurring and atypical forms [1332-21-4] |
National Center for Environmental Health/Agency for Toxic Substances and Disease Registry U.S. Environmental Protection Agency |
Widespread community exposure in certain geographic locales; insufficient dose-response data to characterize risk from exposure to "unregulated" asbestiform mineral fibers and naturally occurring fibrous mineral "mixtures" (1, 2, 6, 7) |
|
Substance |
Nominated by |
Nomination Rationale |
Preliminary Study Recommendations |
---|---|---|---|
Diethyl phthalate [84-66-2] |
National Institute of Environmental Health Sciences | Widespread consumer exposure through use in cosmetics and personal care products; insufficient toxicity data to assess potential reproductive hazard (1, 6, 7) |
|
Substance |
Nominated by |
Nomination Rationale |
Preliminary Study Recommendations |
---|---|---|---|
2',2'''-Dithiobisbenzanilide [135-57-9] |
National Cancer Institute | High production volume; potential worker and consumer exposures; lack of adequate toxicological data; suspicion of toxicity based on structure (1, 6, 7) |
|
Substance |
Nominated by |
Nomination Rationale |
Preliminary Study Recommendations |
---|---|---|---|
2-Methoxy-4-nitroaniline [97-52-9] |
National Cancer Institute | High production volume; potential worker exposures; lack of adequate toxicological data; positive mutagenicity data; strong suspicion of toxicity and carcinogenicity based on structure (1, 6, 7) |
|
Substance |
Nominated by |
Nomination Rationale |
Preliminary Study Recommendations |
---|---|---|---|
Nanoscale materials
|
U.S. Food and Drug Administration | Widespread and increasing use in drug, food and cosmetic products; lack of adequate toxicological and pharmacokinetic data; need to evaluate whether the current required tests are adequate to detect adverse biological and toxicological events (1, 6, 7) |
|
Substance |
Nominated by |
Nomination Rationale |
Preliminary Study Recommendations |
---|---|---|---|
o-Phthalaldehyde [643-79-8] |
National Institute for Occupational Safety and Health | Widespread and increasing use as a disinfectant in health care settings; lack of adequate and publicly available toxicological data; potential skin and respiratory sensitizer (1, 6, 7) | Toxicological characterization including studies to assess dermal irritation, dermal toxicity, and sensitization and asthmagenic potential |
Substance |
Nominated by |
Nomination Rationale |
Preliminary Study Recommendations |
---|---|---|---|
Pentaethylenehexamine [4067-16-7] |
National Cancer Institute | High production volume; potential worker exposures; lack of adequate toxicological data; positive mutagenicity data (1, 6, 7) | No studies at this time due to the irritant and corrosive nature of this compound |
Web page last updated on September 04, 2008