| Agent Name |
Glycidol |
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| Alternative Name |
2,3-Epoxy-1-propanol |
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| CAS Number |
556-52-5 |
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| Formula |
C3-H6-O2 |
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| Major Category |
Plastics & Rubber |
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| Synonyms |
1,2-Epoxy-3-hydroxypropane; 1-Hydroxy-2,3-epoxypropane; 1-Propanol, 2,3-epoxy-; 2,3-Epoxy-1-propanol; 2,3-Epoxypropanol; 2-(Hydroxymethyl)oxirane; 2-Hydroxymethyloxiran; 3-Hydroxy-1,2-epoxypropane; 3-Hydroxypropylene oxide; Allyl alcohol oxide; Epihydrin alcohol; Epoxypropyl alcohol; Glycide; Glycidol; Glycidyl alcohol; Hydroxymethyl ethylene oxide; Methanol, oxiranyl-; Monoepoxide glycidol; Oxiranemethanol; Oxiranylmethanol; [ChemIDplus] UN2810 |
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| Category |
Epoxy Resins |
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| Description |
Colorless, slightly viscous liquid; [HSDB] |
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| Sources/Uses |
Used primarily as a stabilizer of vinyl polymers; [ACGIH] |
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| Comments |
Mice and rats exposed to high concentrations develop pneumonitis and emphysema; Rabbits show skin irritation and reversible corneal burns after skin and eye exposure; [ACGIH] In lethal inhalation studies of rodents, pulmonary edema was usually the cause of death; There is no experimental data, but glycidol, an epoxide, should be considered a potential skin and respiratory sensitizer; [HSDB] |
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| Exposure Assessment |
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| Skin Designation (ACGIH) |
No |
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| TLV (ACGIH) |
2 ppm |
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| PEL (OSHA) |
50 ppm |
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| IDLH (NIOSH) |
150 ppm |
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| Excerpts from Documentation for IDLHs |
Other animal data: It has been reported that rats exposed repeatedly to 400 ppm for 7 hours per day, 5 days a week for 10 weeks showed no evidence of cumulative toxicity, only very slight irritation of the eyes, and slight lacrimation and respiratory distress following the first few exposures [Hine et al. 1956].
Human data: None relevant for use in determining the revised IDLH |
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| Vapor Pressure |
5.59 mm Hg |
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| Lethal Concentration |
LC50 (rats) = 580 ppm/8H |
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| Explanatory Notes |
Flash point = 162 deg F; VP =0.9 mm Hg @ 25 deg C; [HSDB] |
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| Reference Link |
International Chemical Safety Cards (WHO/IPCS/ILO) |
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| Adverse Effects |
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| Toxic Pneumonitis |
Yes |
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| Dermatotoxin |
Skin Burns |
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| IARC Carcinogen |
Probable Carcinogen |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: GLYCIDOL
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