| Agent Name |
Toluene-2,4-diisocyanate |
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| Alternative Name |
TDI |
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| CAS Number |
584-84-9; 26471-62-5 |
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| Formula |
C9-H6-N2-O2 |
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| Major Category |
Plastics & Rubber |
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| Synonyms |
2,4-Diisocyanato-1-methylbenzene; 2,4-Diisocyanatotoluene; 2,4-TDI; 2,4-Tolylene diisocyanate; 4-Methyl-m-phenylene diisocyanate; Benzene, 2,4-diisocyanato-1-methyl-; Cresorcinol diisocyanate; Desmodur T80; Di-iso-cyanatoluene; Di-isocyanate de toluylene [French]; Diisocyanat-toluol [German]; Hylene T; Hylene tlc; Isocyanic acid, 4-methyl-m-phenylene ester; Mondur TD; Mondur TD-80; Mondur TDS; Nacconate IOO; TDI; TDI-80; Tolueen-diisocyanaat [Dutch]; Toluen-disocianato [Italian]; Toluene, 2,4-diisocyanato-; Toluene-2,4-diisocyanate; Toluilenodwuizocyjanian [Polish]; Toluylene-2,4-diisocyanate; Tolyene 2,4-diisocyanate; Tolylene diisocyanate; Tolylene-2,4-diisocyanate; Tuluylendiisocyanat [German]; [ChemIDplus] UN2078 |
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| Category |
Diisocyanates |
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| Description |
Colorless to pale-yellow solid or liquid (above 71 degrees F) with a sharp, pungent odor; [NIOSH] |
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| Sources/Uses |
Occupational asthma reported in floor varnishers and in workers manufacturing polyurethane foams and elastomers; [Malo] |
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| Comments |
Liquid causes second degree burns after contact for a few minutes. [CHRIS] May cause skin sensitization and pulmonary edema; [ICSC] Cases of hypersensitivity pneumonitis (TDI HP and MDI HP) have been reported. [Rom, p. 388-90] Can cause lacrimation, photophobia, and lid edema; [HSDB] See Sennbro CJ, et al. Biological monitoring of exposure to toluene diisocyanate. Scand J Work Environ Health 2004;30(5):371-378] See "DIISOCYANATES." |
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| Reference Link |
Occupational asthma due to isocyanates |
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| Exposure Assessment |
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| Skin Designation (ACGIH) |
No |
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| TLV (ACGIH) |
0.005 ppm |
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| STEL (ACGIH) |
0.02 ppm |
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| PEL (OSHA) | Ceiling(OSHA) = 0.02 ppm |
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| IDLH (NIOSH) | 2.5 ppm |
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| Excerpts from Documentation for IDLHs |
Basis for revised IDLH: The revised IDLH for toluene�2,4�diisocyanate is 2.5 ppm based on acute inhalation toxicity data in animals [Duncan et al. 1962]. Since in sensitized individuals, even concentrations below the OSHA PEL are capable of triggering the allergic response, the revised IDLH has not been based on data obtained from the exposures of individuals or animals sensitized to TDI. |
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| Vapor Pressure |
0.008 mm Hg |
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| Odor Threshold Low |
0.05 ppm |
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| Odor Threshold High |
2.4 ppm |
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| Lethal Concentration |
LC50 (rats) = 14 ppm/4 hr |
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| Explanatory Notes |
Odor threshold from CHEMINFO; See 2008 Notice of Intended Changes. [ACGIH] Flash point = 127 deg C; [ICSC] |
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| Half Life |
Whole body: a few hours; [TDR, p. 1156] |
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| Reference Link |
ATSDR Medical Management -Toluene diisocyanate |
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| Flammability (NFPA) |
1: must be preheated |
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| Adverse Effects |
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| Asthma |
Yes |
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| Toxic Pneumonitis |
Yes |
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| Fibrogenic |
Yes |
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| Dermatotoxin |
Skin Burns |
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| Skin Sensitizer |
Yes |
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| Lacrimator |
Yes |
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| IARC Carcinogen |
Possible Carcinogen |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: TOLUENE DIISOCYANATE 2,4-TOLUENE DIISOCYANATE
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