| Agent Name |
1,2-Benzisothiazolin-3-one |
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| Alternative Name |
BIT |
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| CAS Number |
2634-33-5 |
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| Formula |
C7-H5-N-O-S |
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| Major Category |
Other Uses |
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| Synonyms |
1,2-Benzisothiazol-3(2H)-one; 1,2-Benzisothiazolin-3-one; IPX; Proxan; Proxel PL; [ChemIDplus] |
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| Category |
Preservatives/Disinfectants |
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| Sources/Uses |
Used as a preservative in manufacturing, pottery molding, plumbing, printing, and laboratory analysis; [Kanerva, p. 1183] |
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| Comments |
Allergic contact dermatitis reported in workers using this preservative, mainly in manufacturing industries (paint, paper, rubber, and air fresheners); [Kanerva, p. 1183] Occupational asthma reported in a chemical worker; [Malo] |
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| Reference Link |
1,2-Benzisothiazolin-3-one (Proxel): irritant or allergen? A clinical study and literature review |
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| Exposure Assessment |
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| Skin Designation (ACGIH) |
Not evaluated |
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| Explanatory Notes |
"Danger of sensitization of skin." [MAK] |
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| Reference Link |
Occupational asthma and rhinitis caused by 1,2-benzisothiazolin-3-one in a chemical worker |
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| Adverse Effects |
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| Asthma |
Yes |
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| Skin Sensitizer |
Yes |
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| Links to Other NLM Databases |
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