Agent Name |
Hexamethylene diisocyanate |
CAS Number |
822-06-0 |
Formula |
C8-H12-N2-O2 |
Major Category |
Plastics & Rubber |
Synonyms |
1,6-Diisocyanatohexane; 1,6-Hexamethylene diisocyanate; 1,6-Hexanediol diisocyanate; 1,6-Hexylene diisocyanate; HDI; HMDI; Hexamethylendiisokyanat [Czech]; Hexamethylene-1,6-diisocyanate; Hexane 1,6-diisocyanate; Hexane, 1,6-diisocyanato-; Isocyanic acid, diester with 1,6-hexanediol; Metyleno-bis-fenyloizocyjanian [Polish]; Szesciometylenodwuizocyjanian [Polish]; TL 78; [ChemIDplus] |
Category |
Diisocyanates |
Description |
Clear, colorless to slightly yellow liquid with a sharp, pungent odor; [NIOSH] |
Sources/Uses |
Used as a cross-linking agent to manufacture dental materials, contact lenses, medical adsorbents, and polyurethanes; may be released during the spraying of polyurethane paints; commonly used as a hardener in polyurethane automobile paints; [HSDB] Occupational asthma reported in a spray painter; [Malo] |
Comments |
"Isocyanate HP," a form of hypersensitivity pneumonitis, has been reported. [Rosenstock, p. 346] May cause skin sensitization; [ICSC] See "DIISOCYANATES." |
Reference Link |
ATSDR ToxFAQs - Hexamethylene Diisocyanate |
Exposure Assessment |
Skin Designation (ACGIH) |
No |
TLV (ACGIH) |
0.005 ppm |
MAK |
0.005 ppm |
Vapor Pressure |
0.5 mm Hg |
Lethal Concentration |
LCLo (rats) = 60 mg/m3/4h |
Reference Link |
Evaluation of pulmonary function in workers exposed to hexamethylene diisocyanate |
Adverse Effects |
Asthma |
Yes |
Fibrogenic |
Yes |
Skin Sensitizer |
Yes |
Links to Other NLM Databases |
Health Studies |
Human Health Effects from Hazardous Substances Data Bank: HEXAMETHYLENE DIISOCYANATE
|
|
|