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National Cancer Institute U.S. National Institutes of Health www.cancer.gov
About DCEG

Maria Teresa Landi, M.D., Ph.D.

Senior Investigator

Location: 6120 Executive Blvd., Executive Plaza South, Room 7114
Phone: 301-402-9519
Fax: 301-402-4489
E-mail: landim@mail.nih.gov

 Maria Teresa Landi, M.D., Ph.D.

Biography

Dr. Landi received an M.D. with honors from the University of Milan, Italy, and was trained in oncology and general medicine at the San Raffaele Hospital, University of Milan. She received a Ph.D. in occupational medicine and industrial hygiene, subgroup of molecular epidemiology, from an Italian University Consortium in 1993, and qualified for the associate professorship in occupational medicine and industrial hygiene in the Italian Universities in 1998. Dr. Landi received tenure at the Genetic Epidemiology Branch (GEB) in 2006. Dr. Landi is Associate Professor of Epidemiology at The Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD, and Adjunct Professor of Epidemiology at the George Washington University, School of Public Health and Health Services, Washington, D.C.

Research Interests

  • To study the genetic and environmental determinants of lung cancer using an integrative approach that allows the investigation of the process that begins with smoking initiation and persistence, continues with lung cancer development, and ends with progression to disseminated disease or response to therapy and survival.
  • To investigate the genetic and environmental determinants of cutaneous malignant melanoma in the general population and in high-risk families; in particular, to explore the relationship of UV radiation, pigmentation, and other host factors in the etiology of melanoma.
  • To examine the role of dioxins on cancer risk in highly exposed populations, by means of markers of exposure and early effect.
  • To explore new approaches using high-throughput techniques and genome-wide association studies in the etiology of complex diseases.

Keywords

  • Lung cancer, Melanoma, Pigmentation, Smoking, TCDD, Dioxin, Genome-wide association studies, Molecular epidemiology

Selected Publications

  • Landi MT, Dracheva T, Rotunno M, Figueroa JD, Liu H, Dasgupta A, Mann F, Fukuoka J, Hames M, Bergen AW, Murphy SE, Yang P, Pesatori AC, Consonni D, Bertazzi PA, Wacholder S, Shih JH, Caporaso N, Jen J. Gene expression signature of cigarette smoking in lung parenchyma and its role in lung adenocarcinoma risk and survival. PLoS ONE 2008; 3:e1651.
  • Gerstenblith M, Goldstein A, Landi MT. Comprehensive Evaluation of Allele Frequency Differences of MC1R Variants Across Populations. Hum Mut 2007; 28:495-505.
  • Landi MT, Bauer J, Pfeiffer RM, Elder DE, Hulley B, Minghetti P, Calista D, Kanetsky PA, Pinkel D, Bastian BC. MC1R Germline Variants Confer Risk for BRAF-Mutant Melanoma; ScienceExpress, 29 June 2006; Page 1/10.1126/science1127515. Reprint | Abstract
  • Baccarelli A, Pesatori AC, Consonnni D, Patterson D Jr., Bertazzi PA, Dolken G, Landi MT. Dioxin Exposure is Associated with Increased t(14;18) Translocations in Lymphocytes of Healthy Subjects from Seveso, Italy. Carcinogenesis 2006; 27:2001-2007.
  • Landi MT, Kanetsky PA, Tsang S, Gold B, Munroe D, Rebbeck T, Swoyer J, Ter-Minassian M, Hedayati M, Grossman L, Goldstein AM, Calista D, Pfeiffer RM. MC1R, ASIP, and DNA repair in sporadic and familial melanoma in a Mediterranean population.  J Natl Cancer Inst 2005; 97:998-1007.
  • Baccarelli A, Pesatori A, Consonni D, Mocarelli P, Patterson D Jr., Caporaso N, Bertazzi PA, Landi MT. Health Status and Plasma Dioxin Levels in Chloracne Cases Twenty Years after the Seveso, Italy Accident. Br J Dermatol 2005; 152:459-465.
  • Landi MT, Goldstein A, Tsang S, Munroe D, Modi W, Ter-Minassian M, Steighner R, Dean M, Metheny N, Staats B, Agatep R, Hogg D, Calista D. Genetic susceptibility in familial melanoma from northeastern Italy. J Med Genet 2004;41:557-566.
  • Landi MT, Bertazzi PA, Baccarelli A, Consonni D, Masten S, Lucier G, Mocarelli P, Needham L, Caporaso N, Grassman J. TCDD-mediated alterations in the AhR-dependent pathway in Seveso, Italy, 20 years after the accident. Carcinogenesis 2003;24:673-680.
  • Brenner AV, Lubin JH, Calista D, Landi MT. Instrumental Measurements of Skin Color and Skin Ultraviolet Light Sensitivity and Risk of Cutaneous Malignant Melanoma: A Case-Control Study in an Italian Population. Am J Epidemiol 2002; 156:353-362.
  • Landi MT et al. DNA repair, dysplastic nevi and sunlight sensitivity in the development of cutaneous malignant melanoma. J Natl Cancer Inst 2002; 94: 94-101.