Biography

Dr. Goldstein received a Ph.D. in genetic epidemiology from the University of California at Los Angeles in 1988, after which she joined the NCI Environmental Epidemiology Branch as an Intramural Research Training Award Fellow. Dr. Goldstein completed a fellowship in the NIH Interinstitute Medical Genetics Program, and became board certified in medical genetics in 1993. Her research focuses on family and genetic epidemiologic studies to elucidate genetic and environmental determinants of cancer.

Research Interests

• Identification of genetic and environmental risk factors for cancer
• Linkage and other genetic analyses of familial cancer
• Development and examination of methodology to study genetic and environmental influences on the development of cancer

Keywords

CDK4, CDKN2A, gene-environment interactions, genetic epidemiology, hereditary cancer, melanoma, p16, PTCH, nevoid basal cell carcinoma, MC1R

Selected Publications

• Gerstenblith MR, et al. Comprehensive evaluation of allele frequency differences of MC1R variants across populations. Hum Mutat 2007;28(5):495-505.
• Goldstein AM, et al. Features associated with germline CDKN2A mutations: a GenoMEL study of melanoma-prone families from three continents. J Med Genet 2007;44(2):99-106.
• Goldstein AM, et al. High-risk melanoma susceptibility genes and pancreatic cancer, neural system tumors, and uveal melanoma across GenoMEL. Cancer Res 2006;66(20):9818-9828.
• Goldstein AM, et al. Unconditional analyses can increase efficiency in assessing gene-environment interaction of the case-combined-control design. Int J Epidemiol 2006;35(4):1067-1073.
• Yang R, et al. Influence of glutathione-S-transferase (GSTM1, GSTP1, GSTT1) and cytochrome p450 (CYP1A1, CYP2D6) polymorphisms on numbers of basal cell carcinomas (BCCs) in families with the naevoid basal cell carcinoma syndrome. J Med Genet 2006;43(4):e16.
• Goldstein AM, et al. Association of MC1R variants and risk of melanoma in melanoma-prone families with CDKN2A mutations. Cancer Epidemiol Biomarkers Prev 2005;14:2208-2212.
• Ng D, et al. Restrospective family study of childhood medulloblastoma. Am J Med Genet 2005;134A:399-403.
• Andrieu N, et al. The case-combined-control design was efficient in detecting gene-environment interactions. J Clin Epidemiol 2004;57:662-671.
• Goldstein AM, et al. Prospective risk of cancer in CDKN2A germline mutation carriers. J Med Genet 2004;41:421-424.