Biography

Dr. Caporaso received his undergraduate degree from Rutgers University and his M.D. from the University of New Jersey. In 1983 he came to the National Cancer Institute (NCI) as an Oncology fellow in the Medicine Branch. He has served as a research fellow and biotechnology fellow in the Environmental Epidemiology Branch of NCI. Since 1996, he has been the Chief of the Pharmacogenetics Section, Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics. He is a current member of the Prostate, Lung, Colorectal and Ovarian (PLCO) steering committee, the DCEG Lung Cancer Interest Group, the NCI Program Review Group for Lung Cancer, the World Trade Center Health Registry Scientific Advisory Committee, and the National Lung Screening Trial (NLST) Biomarkers Subcommittee. In addition, he serves as the NCI Tobacco Co-Champion to set priorities and guide implementation of tobacco-related research, and Co-Chair of theTobacco Research Opportunity Team.

Research Interests

• Molecular epidemiology of lung cancer and tobacco
• Etiology of chronic lymphocytic leukemia and related hematologic and lymphoproliferative conditions

Keywords

lung cancer, chronic lymphocytic leukemia, molecular epidemiology, tobacco, nicotine dependency

Selected Publications

• Wacholder S, Chatterjee N, Caporaso N. Intermediacy and gene-environment interaction: the example of CHRNA5-A3 region, smoking, nicotine dependence, and lung cancer. J Natl Cancer Inst. 2008 Nov 5;100(21): 1488-91. Epub 2008 Oct 28.
• Goldin LR, Caporaso NE. Family studies in chronic lymphocytic leukaemia and other lymphoproliferative tumours. Br J Haematol 2007 Dec;139(5):774-9. Review.
• McMaster ML, Caporaso N. Waldenström macroglobulinaemia and IgM monoclonal gammopathy of undetermined significance: emerging understanding of a potential precursor condition . Br J Haematol 2007 Dec;139(5):663-71. Review.
• Landi MT, Consonni D, Rotunno M, Bergen AW, Goldstein AM, Lubin JH, Goldin L, Alavanja M, Morgan G, Subar AF, Linnoila I, Previdi F, Corno M, Rubagotti M, Marinelli B, Albetti B, Colombi A, Tucker M, Wacholder S, Pesatori AC, Caporaso NE, Bertazzi PA. Environment And Genetics in Lung cancer Etiology (EAGLE) study: an integrative population-based case-control study of lung cancer . BMC Public Health 2008; doi: 10.1186/1471-2458-8-203.
• Landi MT, Dracheva T, Rotunno M, Figueroa JD, Liu H, Dasgupta A, Mann FE, Fukuoka J, Hames M, Bergen AW, Murphy SE, Yang P, Pesatori AC, Consonni D, Bertazzi PA, Wacholder S, Shih JH, Caporaso NE, Jen J. Gene expression signature of cigarette smoking and its role in lung adenocarcinoma development and survival . PLoS ONE 2008 Feb 20;3(2):e1651.
• Landgren O, Katzmann JA, Hsing AW, Pfeiffer RM, Kyle RA, Yeboah ED, Biritwum RB, Tettey Y, Adjei AA, Larson DR, Dispenzieri A, Melton LJ 3rd, Goldin LR, McMaster ML, Caporaso NE, Rajkumar SV. Prevalence of monoclonal gammopathy of undetermined significance among men in Ghana. Mayo Clin Proc . 2007 Dec;82(12):1468-73.
• Caporaso N, Goldin L, Plass C, Calin G, Marti G, Bauer S, Raveche E, McMaster ML, Ng D, Landgren O, Slager S. Chronic lymphocytic leukaemia genetics overview. Br J Haematol 2007;139(5):630-4. Review.
• Marti GE, Rawstron AC, Ghia P, Hillmen P, Houlston RS, Kay N, Schleinitz TA, Caporaso N on behalf of the International Familial CLL Consortium. Diagnostic criteria for monoclonal B-cell lymphocytosis. Br J Haematol 2005;130:325-332.
• Yang SH, Mechanic LE, Yang P, Landi MT, Bowman ED, Wampfler J, Meerzaman D, Hong KM, Mann F, Dracheva T, Fukuoka J, Travis W, Caporaso NE, Harris CC, Jen J. Mutations in the tyrosine kinase domain of the epidermal growth factor receptor in non-small-cell lung cancer. Clin Cancer Res 2005;11:2106-2110.
• Caporaso N, Marti GE, Goldin L. Perspectives on familial chronic lymphocytic leukemia: genes and the environment. Semin Hematol 2004;41:201-206.
• Goldin LR, et al., Caporaso N. A genome scan of 18 families with chronic lymphocytic leukemia. Br J Haematol 2003;121:866-873.
• Marti GE, Carter P, Abbasi F., Caporaso N. B Cell Monoclonal Lymphocytosis and B cell abnormalities in familial B-CLL. Cytometry 2003, 52B: 1-12.