NIMH

MOOD AND ANXIETY DISORDERS PROGRAM

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Daniel S. Pine, M.D.

      This section examines the relationships among brain development, emotion regulation, and risk for mood and anxiety disorders in children and adolescents. The broad goal of the section is to define the manner in which developmental changes in brain function relate to normal changes in emotion regulation during development and to mood or anxiety disorders manifest in children and adolescents. To accomplish this goal, the section emphasizes application of fMRI to questions on emotional development, performing fMRI studies using various traditional paradigms from cognitive and affective neuroscience. However, fMRI provides only one tool used to define the manner in which changes in brain systems relate to development and to manifestations of mood and anxiety disorders across the lifespan. Other projects will use behavioral measures of emotion regulation, genetically informative research designs, and treatment strategies. Overall, the planned studies will answer questions in children and adolescents on neural correlates of developmental changes in emotional regulation, risk or symptom patterns in mood and anxiety disorders, as well as the effects of treatments for mood and anxiety disorders on the Developing brain.


          

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This page was last updated: 03/18/2005.