Metabolic Derangements in Acute Heart Failure Syndrome

This study is currently recruiting participants.

Verified by The Cleveland Clinic, May 2008

Sponsored by:	The Cleveland Clinic
Information provided by:	The Cleveland Clinic
ClinicalTrials.gov Identifier:	NCT00682175

Purpose

To determine the association of both neurohormonal and hemodynamic alterations associated with metabolic abnormalities in acute heart failure syndrome.

Condition	Intervention
Congestive Heart Failure	Other: Observational

MedlinePlus related topics: Heart Failure

U.S. FDA Resources

Study Type:	Observational
Study Design:	Case-Only, Prospective
Official Title:	Metabolic Derangements in Acute Heart Failure Syndrome

Further study details as provided by The Cleveland Clinic:

Biospecimen Retention: Samples Without DNA

Biospecimen Description:

serum, plasma

Estimated Enrollment:	100
Study Start Date:	May 2008
Estimated Study Completion Date:	December 2009
Estimated Primary Completion Date:	June 2009 (Final data collection date for primary outcome measure)

Groups/Cohorts	Assigned Interventions
Observation Adult (age > 18 yrs) patients admitted to the Heart Failure Intensive Care Unit with Acute Heart Failure Syndrome requiring placement of a Pulmonary Artery catheter for hemodynamically guided therapy.	Other: Observational Pulmonary Artery pressure (PA), pulmonary capillary wedge pressure (PCWP), cardiac output (CO), and cardiac index (CI). This data will be collected after 24 ± 2 and 48 ± 2 hours of standard heart failure therapy

Eligibility

Ages Eligible for Study:	18 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No
Sampling Method:	Non-Probability Sample

Study Population

Adult (age > 18 yrs) patients admitted to the Heart Failure Intensive Care Unit (H22) with Acute Heart Failure Syndrome (AHFS) requiring placement of a Pulmonary Artery catheter for hemodynamically guided therapy.

Criteria

Inclusion Criteria:

Adult (age > 18 yrs) patients admitted to the Heart Failure Intensive Care Unit (H22) with Acute Heart Failure Syndrome (AHFS) requiring placement of a Pulmonary Artery catheter for hemodynamically guided therapy.

Exclusion Criteria:

History of Congenital Heart Disease.
Acute HF in the setting of acute myocardial infarction.
Severe Anemia
Patients listed for cardiac transplantation.
Terminal Malignancy, AIDS or CNS disease.
Concomitant sepsis, ARDS, trauma, aortic dissection, or pericardial tamponade

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00682175

Contacts

Contact: George Sokos, MD

216-444-2200

sokosg@ccf.org

Locations

United States, Ohio
Cleveland Clinic	Recruiting
Cleveland, Ohio, United States, 44185
Contact: George Sokos, MD 216-444-2200 sokosg@cc.org
Principal Investigator: George Sokos, MD

Sponsors and Collaborators

The Cleveland Clinic

Investigators

Principal Investigator:

George Sokos, MD

The Cleveland Clinic

More Information

Responsible Party:	Cleveland Clinic Foundation ( George Sokos, MD )
Study ID Numbers:	08-169
Study First Received:	May 20, 2008
Last Updated:	May 20, 2008
ClinicalTrials.gov Identifier:	NCT00682175
Health Authority:	United States: Institutional Review Board

Keywords provided by The Cleveland Clinic:

Congestive Heart Failure

Study placed in the following topic categories:

Heart Failure
Heart Diseases

Additional relevant MeSH terms:

Cardiovascular Diseases

ClinicalTrials.gov processed this record on January 16, 2009