Research Interests

     This unit focuses on the identification and characterization of bioactive components of biological fluids and tissues. Other projects of interest are drawn from proteins that are of medical interest due to their ability to interact with binding partners, their allergic properties or their resulting modification/ alteration by compounds normally prescribed in a medical setting or their propensity to cause or alter disease states. The group makes use of mass spectral techniques such as SELDI, MALDI and MS/MS to study, define and interpret the changes in protein expression and structure in biological systems.

Selected Bibliography

Caputo E, Moharram R, Martin BM. "Methods for on-chip protein analysis."  Anal Biochem. 2003 Oct 1;321(1):116-24.
Caputo E, Camarca A, Moharram R, Tornatore P, Thatcher B, Guardiola J, Martin BM. "Structural study of GCDFP-15/gp17 in disease versus physiological conditions using a proteomic approach." Biochemistry. 2003 May 27;42(20):6169-78.

Mannes AJ, Martin BM, Yang HY, Keller JM, Lewin S, Gaiser RR, Iadarola MJ. "Cystatin C as a cerebrospinal fluid biomarker for pain in humans." Pain. 2003 Apr;102(3):251-6.

Yan WL, Guan XY, Green ED, Nicolson R, Yap TK, Zhang J, Jacobsen LK, Krasnewich DM, Kumra S, Lenane MC, Gochman P, Damschroder-Williams PJ, Esterling LE, Long RT, Martin BM, Sidransky E, Rapoport JL, Ginns EI.  "Childhood-onset schizophrenia/autistic disorder and t(1;7) reciprocal translocation: identification of a BAC contig spanning the translocation breakpoint at 7q21." Am J Med Genet. 2000 Dec 4;96(6):749-53.

Ginns EI, St Jean P, Philibert RA, Galdzicka M, Damschroder-Williams P, Thiel B, Long RT, Ingraham LJ, Dalwaldi H, Murray MA, Ehlert M, Paul S, Remortel BG, Patel AP, Anderson MC, Shaio C, Lau E, Dymarskaia I, Martin BM, Stubblefield B, Falls KM, Carulli JP, Keith TP, Fann CS, Paul SM, et al.  "A genome-wide search for chromosomal loci linked to mental health wellness in relatives at high risk for bipolar affective disorder among the Old Order Amish."  Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15531-6.