The cardio vascular diseases are the main cause of death all around the world. About 45% of the death in Iran relates to this disease. We therefore aimed to establish whether use of evidence-based combination drug regimens such as polypill is efficacious and safe to use in primary prevention. There are some studies, which established that four effective medicines in one tablet had a better compliance of the patients and had fewer side effects.

Methods:

The first double blind clinical research was designed to study morbidity and mortality in 2 groups of patients in a randomized manner 500 healthy volunteers and will be followed up for 1 year. One group will take a tablet of polypill, which contain three types of medicine effective in cardio vascular disease. This tablet contains a drug of preventing platelet aggregation aspirin (81mg), two drugs of reducing blood pressure containing ACE inhibitor enalapril (2.5mg) and one diuretic drug such as hydrochlorothiazide (12.5mg) and one reducing hyperlipidemia from the group of Statins Atorvastatin (20mg) and in the other group will take placebo.