A. Healthy volunteers

Inclusion Criteria:

1. Men ranging in age from 18-40 years.
2. In good general health as determined by medical history, physical examination, ECG and clinical laboratory tests obtained with 14 days prior to the start of the study.
3. BMI<30 or the volunteer is not considered obese by the Principal Investigator with a written statement at screening.
4. Willing and able to abide by the dietary requirements of the study.
5. Willing and able to give written informed consent in a manner approved by the Institutional Review Board or Ethics Committee.

Exclusion Criteria:

1. History of known or suspected clinically significant hypersensitivity to any drug.
2. History or presence of any disease or condition known to interfere with the absorption, distribution, metabolism or excretion of drugs.
3. Clinically significant cardiovascular, hepatic, gastrointestinal, metabolic, neurological, pulmonary, endocrine, psychiatric, coagulation or neoplastic disorders.
4. Participation in radiologic studies involving parenteral administration of iodinated contrast materials within two weeks prior to screening.
5. Subjects with history of recent alcohol abuse (defined as consumption of more than 21- ml of alcohol per week; or the equivalent of fourteen 4-oz glasses of wine, fourteen 12 oz can/bottle of beer or wine cooler) or other substance abuse.
6. Any protocol-required laboratory test abnormality that is considered clinically significant.
7. Participation in another investigational drug study within 90 days before the first day of dosing.
8. History of non-compliance to medical regimens, or subjects who are considered potentially unreliable.
9. Blood or plasma donation within the past 90 days.
10. Mentally unstable or incompetent.
11. Positive hepatitis C screen or positive hepatitis B screen.
12. HIV positive

B. Type 2 diabetic patients

Inclusion Criteria:

1. Type 2 male patients and post-menopausal females aged 30-70 years.
2. HA1c 6.5-10%
3. Naïve or treated with Metformin only
4. BMI< 35
5. Willing and able to abide by the dietary requirements of the study.
6. Willing and able to give written informed consent in a manner approved by the Institutional Review Board or Ethics Committee.

Exclusion Criteria:

1. History of known or suspected clinically significant hypersensitivity to any drug.
2. History or presence of any disease or condition known to interfere with the absorption, distribution, metabolism or excretion of drugs.
3. Clinically significant cardiovascular, hepatic, gastrointestinal, metabolic, neurological, pulmonary, endocrine, psychiatric, coagulation or neoplastic disorders.
4. Participation in radiologic studies involving parenteral administration of iodinated contrast materials within two weeks prior to screening.
5. Subjects with history of recent alcohol abuse (defined as consumption of more than 21- ml of alcohol per week; or the equivalent of fourteen 4-oz glasses of wine, fourteen 12 oz can/bottle of beer or wine cooler) or other substance abuse.
6. Any protocol-required laboratory test abnormality that is considered clinically significant.
7. Participation in another investigational drug study within 90 days before the first day of dosing.
8. History of non-compliance to medical regimens, or subjects who are considered potentially unreliable.
9. Blood or plasma donation within the past 90 days.
10. Mentally unstable or incompetent.
11. Positive hepatitis C screen or positive hepatitis B screen.
12. HIV positive