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Sponsored by: |
Istanbul University |
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Information provided by: | Istanbul University |
ClinicalTrials.gov Identifier: | NCT00602264 |
The aim of this study is to determine serum concentrations of adiponectin (ApN), leptin and ghrelin in different stages of anorectic patients and to evaluate their relationships between biochemical, hormonal and anthropometric parameters.
Condition |
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Anorexia Nervosa Adipokines |
Study Type: | Observational |
Study Design: | Case Control, Prospective |
Official Title: | Adipocytokine and Ghrelin Concentrations in Different Stages of Anorexia Nervosa |
Enrollment: | 41 |
Study Start Date: | February 2006 |
Study Completion Date: | May 2007 |
Groups/Cohorts |
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1
Treatment-naïve patients with a recent diagnosis of anorexia nervosa
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2
The weight recovered subgroup of group 1
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3
Recovered patients with a previous history of anorexia nervosa but normal menstrual cycles and body weight at the present time
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4
Control group
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Objective: The aim of this study is to determine serum concentrations of adiponectin (ApN), leptin and ghrelin in different stages of anorectic patients and to evaluate their relationships between biochemical, hormonal and anthropometric parameters.
Design: The study group is composed of four groups. Group1: Treatment-naïve patients with a recent diagnosis of AN (n:19), Group 2: The weight recovered (10 % increase in body weight compared with baseline weight) subgroup of group 1 at the end of a mean 117.72±98.14 days of follow-up (n: 12), Group 3: Recovered patients with a previous history of AN but normal menstrual cycles and body weight at the present time (n:10), Group 4: Control group: constitutionally thin healthy young women with normal menstrual cycles (n:10). Venous blood was obtained for measurements of biochemical parameters, ApN, leptin and ghrelin and body composition was determined by bioimpedance analysis.
Ages Eligible for Study: | 16 Years to 32 Years |
Genders Eligible for Study: | Female |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
Patients with anorexia nervosa and constitutionally thin healthy subjects
Inclusion Criteria:
Exclusion Criteria:
Turkey | |
Istanbul Univetsity, Istanbul Medical Faculty, Department of Psychiatrics | |
Istanbul, Turkey |
Study Director: | Ayse Kubat Uzum, M.D | Istanbul University Istanbul Medical Faculty Department of Endocrinology and Metabolism |
Principal Investigator: | Basak Yucel, Professor | Istanbul University Istanbul Medical Faculty Department of Psychiatrics |
Study Chair: | Beyhan Omer, Professor | Istanbul University Istanbul Medical Faculty Department of Biochemistry |
Study Director: | Nese Colak Ozbey, Professor | Istanbul University Istanbul Medical Faculty Department of Endocrinology and Metabolism |
Responsible Party: | Istanbul University Istanbul Medical Faculty Department of Psychiatrics ( Basak Yucel ) |
Study ID Numbers: | 503/5052006, 2005/1795 |
Study First Received: | January 15, 2008 |
Last Updated: | January 25, 2008 |
ClinicalTrials.gov Identifier: | NCT00602264 |
Health Authority: | Turkey: Ethics Committee |
Anorexia nervosa Adipokines Ghrelin Fat mass |
Signs and Symptoms Signs and Symptoms, Digestive Mental Disorders |
Anorexia Anorexia Nervosa Eating Disorders |