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Laboratory of Neurosciences
Publications -- 2003/2002
2003 Publications

  1. Anson RM, Guo Z, de Cabo R, Iyun T, Rios M, Hagepanos A, Ingram DK, Lane MA, Mattson MP. Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake. Proc Natl Acad Sci USA. 2003;100(10):6216-6220. [Abs]

  2. Cai J, Limke TL, Ginis I, Rao MS. Identifying and tracking neural stem cells. Blood Cells Mol Dis. 2003;31(1):18-27. [Abs]

  3. Cheng A, Wang S, Cai J, Rao MS, Mattson MP. Nitric oxide acts in a positive feedback loop with BDNF to regulate neural progenitor cell proliferation and differentiation in the mammalian brain. Dev Biol. 2003;258(2):319-333. [Abs]

  4. Cheng A, Wang S, Yang D, Xiao R, Mattson MP. Calmodulin mediates brain-derived neurotrophic factor cell survival signaling upstream of Akt kinase in embryonic neocortical neurons. J Biol Chem. 2003;278(9):7591-7599. [Abs]

  5. Culmsee C, Siewe J, Junker V, Retiounskaia M, Schwarz S, Camandola S, El-Metainy S, Behnke H, Mattson MP, Krieglstein J. Reciprocal inhibition of p53 and nuclear factor-kappaB transcriptional activities determines cell survival or death in neurons. J Neurosci. 2003;23(24):8586-8595. [Abs]

  6. da Costa CA, Mattson MP, Ancolio K, Checler F. The C-terminal fragment of presenilin 2 triggers p53-mediated staurosporine-induced apoptosis, a function independent of the presenilinase-derived N-terminal counterpart. J Biol Chem. 2003;278(14):12064-12069. [Abs]

  7. Doyle ME, Theodorakis MJ, Holloway HW, Bernier M, Greig NH, Egan JM. The importance of the nine-amino acid C-terminal sequence of exendin-4 for binding to the GLP-1 receptor and for biological activity. Regul Pept. 2003;114(2-3):153-158. [Abs]

  8. Duan W, Guo Z, Jiang H, Ware M, Li XJ, Mattson MP. Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice. Proc Natl Acad Sci USA. 2003;100(5): 2911-2916. [Abs]

  9. Duan W, Guo Z, Jiang H, Ware M, Mattson MP. Reversal of behavioral and metabolic abnormalities, and insulin resistance syndrome, by dietary restriction in mice deficient in brain-derived neurotrophic factor. Endocrinology. 2003;144(6):2446-2453. [Abs]

  10. Furukawa K, Wang Y, Yao PJ, Fu W, Mattson MP, Itoyama Y, Onodera H, D'Souza I, Poorkaj PH, Bird TD, Schellenberg GD. Alteration in calcium channel properties is responsible for the neurotoxic action of a familial frontotemporal dementia tau mutation. J Neurochem. 2003;87(2):427-436. [Abs]

  11. Galey D, Becker K, Haughey N, Kalehua A, Taub D, Woodward J, Mattson MP, Nath A. Differential transcriptional regulation by human immunodeficiency virus type 1 and gp120 in human astrocytes. J Neurovirol. 2003;9(3):358-371. [Abs]

  12. Gary DS, Milhavet O, Camandola S, Mattson MP. Essential role for integrin linked kinase in Akt-mediated integrin survival signaling in hippocampal neurons. J Neurochem. 2003;84(4):878-890. [Abs]

  13. Getchell TV, Peng X, Stromberg AJ, Chen KC, Paul Green C, Subhedar NK, Shah DS, Mattson MP, Getchell ML. Age-related trends in gene expression in the chemosensory-nasal mucosae of senescence-accelerated mice. Ageing Res Rev. 2003;2(2):211-243. [Abs]

  14. Gilman CP, Chan SL, Guo Z, Zhu X, Greig N, Mattson MP. p53 is present in synapses where it mediates mitochondrial dysfunction and synaptic degeneration in response to DNA damage, and oxidative and excitotoxic insults. Neuromolecular Med. 2003;3(3):159-172. [Abs]

  15. Gilman CP, Perry T, Furukawa K, Grieg NH, Egan JM, Mattson MP. Glucagon-like peptide 1 modulates calcium responses to glutamate and membrane depolarization in hippocampal neurons. J Neurochem. 2003;87(5):1137-1144. [Abs]

  16. Hasegawa T, Matsuzaki M, Takeda A, Kikuchi A, Furukawa K, Shibahara S, Itoyama Y. Increased dopamine and its metabolites in SH-SY5Y neuroblastoma cells that express tyrosinase. J Neurochem. 2003;87(2):470-475. [Abs]

  17. Haughey NJ, Mattson MP. Alzheimer's amyloid b-peptide enhances ATP/gap junction-mediated calcium-wave propagation in astrocytes. Neuromolecular Med. 2003;3(3):173-180. [Abs]

  18. Lahiri DK, Chen D, Ge YW, Farlow M, Kotwal G, Kanthasamy A, Ingram DK, Greig NH. Does nitric oxide synthase contribute to the pathogenesis of Alzheimer's disease?: effects of b-amyloid deposition on NOS in transgenic mouse brain with AD pathology. Ann NY Acad Sci. 2003;1010:639-642. [Abs]

  19. Lahiri DK, Chen D, Vivien D, Ge YW, Greig NH, Rogers JT. Role of cytokines in the gene expression of amyloid beta-protein precursor: identification of a 5'-UTR-binding nuclear factor and its implications in Alzheimer's disease. J Alzheimers Dis. 2003;5(2):81-90. [Abs]

  20. Lahiri DK, Farlow MR, Sambamurti K, Greig NH, Giacobini E, Schneider LS. A critical analysis of new molecular targets and strategies for drug developments in Alzheimer's disease. Curr Drug Targets. 2003;4(2):97-112. [Abs]

  21. Lee J, Auyeung WW, Mattson MP. Interactive effects of excitotoxic injury and dietary restriction on microgliosis and neurogenesis in the hippocampus of adult mice. Neuromolecular Med. 2003;4(3):179-196. [Abs]

  22. Limke TL, Cai J, Miura T, Rao MS, Mattson MP. Distinguishing features of progenitor cells in the late embryonic and adult hippocampus. Dev Neurosci. 2003;25(2-4):257-272. [Abs]

  23. Liu D, Slevin JR, Lu C, Chan SL, Hansson M, Elmer E, Mattson MP. Involvement of mitochondrial K+ release and cellular efflux in ischemic and apoptotic neuronal death. J Neurochem. 2003;86(4):966-979. [Abs]

  24. Mattson MP. Adventures in neural plasticity, aging, and neurodegenerative disorders aboard the CWC beagle. Neurochem Res. 2003;28(11):1631-1637. [Abs]

  25. Mattson MP. Excitotoxic and excitoprotective mechanisms: abundant targets for the prevention and treatment of neurodegenerative disorders. Neuromolecular Med. 2003;3(2):65-94. [Abs]

  26. Mattson MP. Gene-diet interactions in brain aging and neurodegenerative disorders. Ann Intern Med. 2003;139(5 Pt 2):441-444. [Abs]

  27. Mattson MP. Insulating axons via NF-kappaB. Nat Neurosci. 2003;6(2):105-106.

  28. Mattson MP. Methylation and acetylation in nervous system development and neurodegenerative disorders. Ageing Res Rev. 2003;2(3):329-342. [Abs]

  29. Mattson MP. Neurobiology: Ballads of a protein quartet. Nature. 2003;422(6930):385-387

  30. Mattson MP. Will caloric restriction and folate protect against AD and PD? Neurology. 2003;60(4):690-695. [Abs]

  31. Mattson MP, Chan SL. Calcium orchestrates apoptosis. Nat Cell Biol. 2003;5(12):1041-1043. [Abs]

  32. Mattson MP, Chan SL. Good and bad amyloid antibodies. Science. 2003;301(5641):1847-1849. [Abs]

  33. Mattson MP, and Chan SL. Neuronal and glial calcium signaling in Alzheimer's disease. Cell Calcium, 2003;34:385-397. [Abs]

  34. Mattson MP, Duan W, Guo Z. Meal size and frequency affect neuronal plasticity and vulnerability to disease: cellular and molecular mechanisms. J Neurochem. 2003;84(3):417-431. [Abs]

  35. Mattson MP, Haberman F. Folate and homocysteine metabolism: therapeutic targets in cardiovascular and neurodegenerative disorders. Curr Med Chem. 2003;10(19):1923-1929. [Abs]

  36. Mattson MP, Kroemer G. Mitochondria in cell death: novel targets for neuroprotection and cardioprotection. Trends Mol Med. 2003;9(5):196-205. [Abs]

  37. Mattson MP, Liu D. Mitochondrial potassium channels and uncoupling proteins in synaptic plasticity and neuronal cell death. Biochem Biophys Res Commun. 2003;304(3):539-549. [Abs]

  38. Mattson MP, Perry T, Greig NH. Learning from the gut. Nat Med. 2003;9(9):1113-1115.

  39. Mattson MP, Shea TB. Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders. Trends Neurosci. 2003;26(3):137-146. [Abs]

  40. Mattson MP, Sherman M. Perturbed signal transduction in neurodegenerative disorders involving aberrant protein aggregation. Neuromolecular Med. 2003;4(1-2):109-132. [Abs]

  41. Meneilly GS, Greig N, Tildesley H, Habener JF, Egan JM, Elahi D. Effects of 3 months of continuous subcutaneous administration of glucagon-like peptide 1 in elderly patients with type 2 diabetes. Diabetes Care. 2003;26(10):2835-2841. [Abs]

  42. Milhavet O, Gary DS, Mattson MP. RNA interference in biology and medicine. Pharmacol Rev. 2003;55(4):629-648. [Abs]

  43. Nath A, Hall E, Tuzova M, Dobbs M, Jons M, Anderson C, Woodward J, Guo Z, Fu W, Kryscio R, Wekstein D, Smith C, Markesbery WR, Mattson MP. Autoantibodies to amyloid b-peptide (Ab) are increased in Alzheimer's disease patients and Ab antibodies can enhance Ab neurotoxicity: implications for disease pathogenesis and vaccine development. Neuromolecular Med. 2003;3(1):29-39. [Abs]

  44. Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R, Metherate R, Mattson MP, Akbari Y, LaFerla FM. Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Ab and synaptic dysfunction. Neuron. 2003;39(3):409-421. [Abs]

  45. Pak KJ, Chan SL, Mattson MP. Homocysteine and folate deficiency sensitize oligodendrocytes to the cell death-promoting effects of a presenilin-1 mutation and amyloid beta-peptide. Neuromolecular Med. 2003;3(2):119-128. [Abs]

  46. Pak K, Chan SL, Mattson MP. Presenilin-1 mutation sensitizes oligodendrocytes to glutamate and amyloid toxicities, and exacerbates white matter damage and memory impairment in mice. Neuromolecular Med. 2003;3(1):53-64. [Abs]

  47. Perry T, Greig NH. The glucagon-like peptides: a double-edged therapeutic sword? Trends Pharmacol Sci. 2003;24(7):377-383.

  48. Perry T, Lahiri DK, Sambamurti K, Chen D, Mattson MP, Egan JM, Greig NH. Glucagon-like peptide-1 decreases endogenous amyloid-b peptide (Ab) levels and protects hippocampal neurons from death induced by Ab and iron. J Neurosci Res. 2003;72(5):603-612. [Abs]

  49. Pigino G, Morfini G, Pelsman A, Mattson MP, Brady ST, Busciglio J. Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport. J Neurosci. 2003;23(11):4499-4508. [Abs]

  50. Trojanowski JQ, Mattson MP. Overview of protein aggregation in single, double, and triple neurodegenerative brain amyloidoses. Neuromolecular Med. 2003;4(1-2):1-6. [Abs]

  51. Wan R, Camandola S, Mattson MP. Intermittent fasting and dietary supplementation with 2-deoxy-D-glucose improve functional and metabolic cardiovascular risk factors in rats. FASEB J. 2003;17(9):1133-1134. [Abs]

  52. Wan R, Camandola S, Mattson MP. Intermittent food deprivation improves cardiovascular and neuroendocrine responses to stress in rats. J Nutr. 2003;133(6):1921-1929. [Abs]

  53. Yao PJ, Zhang P, Mattson MP, Furukawa K. Heterogeneity of endocytic proteins: distribution of clathrin adaptor proteins in neurons and glia. Neuroscience. 2003;121(1):25-37. [Abs]

  54. Zhang P, Chan SL, Fu W, Mendoza M, Mattson MP. TERT suppresses apoptotis at a premitochondrial step by a mechanism requiring reverse transcriptase activity and 14-3-3 protein binding ability. FASEB J. 2003;17(6):767-769. [Abs]

  55. Zhu X, Giordano T, Yu QS, Holloway HW, Perry TA, Lahiri DK, Brossi A, Greig NH. Thiothalidomides: novel isosteric analogues of thalidomide with enhanced TNF-a inhibitory activity. J Med Chem. 2003;46(24):5222-5229. [Abs]

2002 Publications

  1. Cai J, Wu Y, Mirua T, Pierce JL, Lucero MT, Albertine KH, Spangrude GJ, Rao MS. Properties of a fetal multipotent neural stem cell (NEP cell). Dev Biol. 2002;251(2):221-240. [Abs]

  2. Chan SL, Culmsee C, Haughey N, Klapper W, Mattson MP. Presenilin-1 mutations sensitize neurons to DNA damage-induced death by a mechanism involving perturbed calcium homeostasis and activation of calpains and caspase-12. Neurobiol Dis. 2002;11(1):2-19. [Abs]

  3. Chan SL, Furukawa K, Mattson MP. Presenilins and APP in neuritic and synaptic plasticity: implications for the pathogenesis of Alzheimer's disease. Neuromolecular Med. 2002;2(2):167-196. [Abs]

  4. Chan SL, Pedersen WA, Zhu H, Mattson MP. Numb modifies neuronal vulnerability to amyloid beta-peptide in an isoform-specific manner by a mechanism involving altered calcium homeostasis: implications for neuronal death in Alzheimer's disease. Neuromolecular Med. 2002;1(1):55-67. [Abs]

  5. Cheng G, Yu Z, Zhou D, Mattson MP. Phosphatidylinositol-3-kinase-Akt kinase and p42/p44 mitogen-activated protein kinases mediate neurotrophic and excitoprotective actions of a secreted form of amyloid precursor protein. Exp Neurol. 2002;175(2):407-414. [Abs]

  6. Conant K, Haughey N, Nath A, St Hillaire C, Gary DS, Pardo CA, Wahl LM, Bilak M, Milward E, Mattson MP. Matrix metalloproteinase-1 activates a pertussis toxin-sensitive signaling pathway that stimulates the release of matrix metalloproteinase-9. J Neurochem. 2002;82(4):885-893. [Abs]

  7. Culmsee C, Gerling N, Lehmann M, Nikolova-Karakashian M, Prehn JH, Mattson MP, Krieglstein J. Nerve growth factor survival signaling in cultured hippocampal neurons is mediated through TrkA and requires the common neurotrophin receptor P75. Neuroscience. 2002;115(4):1089-1108. [Abs]

  8. Cutler RG, Pedersen WA, Camandola S, Rothstein JD, Mattson MP. Evidence that accumulation of ceramides and cholesterol esters mediates oxidative stress-induced death of motor neurons in amyotrophic lateral sclerosis. Ann Neurol. 2002;52(4):448-457. [Abs]

  9. da Costa CA, Paitel E, Mattson MP, Amson R, Telerman A, Ancolio K, Checler F, Mattson MP. Wild-type and mutated presenilins 2 trigger p53-dependent apoptosis and down-regulate presenilin 1 expression in HEK293 human cells and in murine neurons. Proc Natl Acad Sci USA. 2002;99(6):4043-4048. [Abs]

  10. Duan W, Ladenheim B, Cutler RG, Kruman II, Cadet JL, Mattson MP. Dietary folate deficiency and elevated homocysteine levels endanger dopaminergic neurons in models of Parkinson's disease. J Neurochem. 2002;80(1):101-110. [Abs]

  11. Duan W, Zhu X, Ladenheim B, Yu QS, Guo Z, Oyler J, Cutler RG, Cadet JL, Greig NH, Mattson MP. p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism. Ann Neurol. 2002;52(5):597-606. [Abs]

  12. Fu W, Lee J, Guo Z, Mattson MP. Seizures and tissue injury induce telomerase in hippocampal microglial cells. Exp Neurol. 2002;178(2):294-300. [Abs]

  13. Fu W, Lu C, Mattson MP. Telomerase mediates the cell survival-promoting actions of brain-derived neurotrophic factor and secreted amyloid precursor protein in developing hippocampal neurons. J Neurosci. 2002;22(24):10710-10719. [Abs]

  14. Furukawa K, Wang Y, Chan SL. Cellular calcium dynamics. In Calcium Homeostasis and Signaling in Aging, M.P. Mattson (Ed.), Amsterdam, Netherlands: Elsevier, pp. 27-45, 2002.

  15. Gary DS, Getchell TV, Getchell ML, Mattson MP. Olfactory bulbectomy protects hippocampal pyramidal neurons against excitotoxic death. Exp Neurol. 2002;176(1):266-268. [Abs]

  16. Gary DS, Mattson MP. PTEN regulates Akt kinase activity in hippocampal neurons and increases their sensitivity to glutamate and apoptosis. Neuromolecular Med. 2002;2(3):261-269. [Abs]

  17. Gilman CP, Mattson MP. Do apoptotic mechanisms regulate synaptic plasticity and growth-cone motility? Neuromolecular Med. 2002;2(2):197-214. [Abs]

  18. Greig NH, Lahiri DK, Sambamurti K. Butyrylcholinesterase: an important new target in Alzheimer's disease therapy. Int Psychogeriatr. 2002;14 Suppl 1:77-91. [Abs]

  19. Han SS, Kang DY, Mujtaba T, Rao MS, Fischer I. Grafted lineage-restricted precursors differentiate exclusively into neurons in the adult spinal cord. Exp Neurol. 2002;177(2):360-375. [Abs]

  20. Haughey NJ, Liu D, Nath A, Borchard AC, Mattson MP. Disruption of neurogenesis in the subventricular zone of adult mice, and in human cortical neuronal precursor cells in culture, by amyloid beta-peptide: implications for the pathogenesis of Alzheimer's disease. Neuromolecular Med. 2002;1(2):125-135. [Abs]

  21. Haughey NJ, Mattson MP. Calcium dysregulation and neuronal apoptosis by the HIV-1 proteins Tat and gp120. J Acquir Immune Defic Syndr. 2002;31 Suppl 2:S55-61. [Abs]

  22. Haughey NJ, Nath A, Chan SL, Borchard AC, Rao MS, Mattson MP. Disruption of neurogenesis by amyloid beta-peptide, and perturbed neural progenitor cell homeostasis, in models of Alzheimer's disease. J Neurochem. 2002;83(6):1509-1524. [Abs]

  23. Kittur S, Wilasrusmee S, Pedersen WA, Mattson MP, Straube-West K, Wilasrusmee C, Lubelt B, Kittur DS. Neurotrophic and neuroprotective effects of milk thistle (Silybum marianum) on neurons in culture. J Mol Neurosci. 2002;18(3):265-269. [Abs]

  24. Kruman II, Kumaravel TS, Lohani A, Pedersen WA, Cutler RG, Kruman Y, Haughey N, Lee J, Evans M, Mattson MP. Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease. J Neurosci. 2002;22(5):1752-1762. [Abs]

  25. LaFontaine MA, Mattson MP, Butterfield DA. Oxidative stress in synaptosomal proteins from mutant presenilin-1 knock-in mice: implications for familial Alzheimer's disease. Neurochem Res. 2002;27(5):417-421. [Abs]

  26. Lahiri DK, Utsuki T, Chen D, Farlow MR, Shoaib M, Ingram DK, Greig NH. Nicotine reduces the secretion of Alzheimer's beta-amyloid precursor protein containing beta-amyloid peptide in the rat without altering synaptic proteins. Ann N Y Acad Sci. 2002;965:364-372. [Abs]

  27. Lee J, Chan SL, Lu C, Lane MA, Mattson MP. Phenformin suppresses calcium responses to glutamate and protects hippocampal neurons against excitotoxicity. Exp Neurol. 2002;175(1):161-167. [Abs]

  28. Lee J, Chan SL, Mattson MP. Adverse effect of a presenilin-1 mutation in microglia results in enhanced nitric oxide and inflammatory cytokine responses to immune challenge in the brain. Neuromolecular Med. 2002;2(1):29-45. [Abs]

  29. Lee J, Duan W, Mattson MP. Evidence that brain-derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice. J Neurochem. 2002;82(6):1367-1375. [Abs]

  30. Lee J, Seroogy KB, Mattson MP. Dietary restriction enhances neurotrophin expression and neurogenesis in the hippocampus of adult mice. J Neurochem. 2002;80(3):539-547. [Abs]

  31. Lee J, Wu Y, Qi Y, Xue H, Liu Y, Cai J, Guillemot F, Qiu M Rao MS. Neurogenin-3 participates in gliogenesis in the developing vertebrate spinal cord. Dev Biol. 2002;253:84-98.

  32. Lilliehook C, Chan S, Choi EK, Zaidi NF, Wasco W, Mattson MP, Buxbaum JD. Calsenilin enhances apoptosis by altering endoplasmic reticulum calcium signaling. Mol Cell Neurosci. 2002;19(4):552-559. [Abs]

  33. Liu D, Lu C, Wan R, Auyeung WW, Mattson MP. Activation of mitochondrial ATP-dependent potassium channels protects neurons against ischemia-induced death by a mechanism involving suppression of Bax translocation and cytochrome c release. J Cereb Blood Flow Metab. 2002;22(4):431-443. [Abs]

  34. Liu Y, Wu Y, Lee JC, Xue H, Pevny LH, Kaprielian Z, Rao MS. Oligodendrocyte and astrocyte development in rodents: an in situ and immunohistological analysis during embryonic development. Glia. 2002;40(1):25-43. [Abs]

  35. Lu C, Chan SL, Fu W, Mattson MP. The lipid peroxidation product 4-hydroxynonenal facilitates opening of voltage-dependent Ca2+ channels in neurons by increasing protein tyrosine phosphorylation. J Biol Chem. 2002;277(27):24368-24375. [Abs]

  36. Lu C, Fu W, Salvesen GS, Mattson MP. Direct cleavage of AMPA receptor subunit GluR1 and suppression of AMPA currents by caspase-3: implications for synaptic plasticity and excitotoxic neuronal death. Neuromolecular Med. 2002;1(1):69-79. [Abs]

  37. Lu C, Fu W, Zhao D, Mattson MP. The DNA damaging agent etoposide activates a cell survival pathway involving alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate receptors and mitogen-activated protein kinases in hippocampal neurons. J Neurosci Res. 2002;70(5):671-679. [Abs]

  38. Luo Y, Cai J, Liu Y, Xue H, Chrest FJ, Wersto RP, Rao M. Microarray analysis of selected genes in neural stem and progenitor cells. J Neurochem. 2002;83(6):1481-1497. [Abs]

  39. Luo Y, Long JM, Lu C, Chan SL, Spangler EL, Mascarucci P, Raz A, Longo DL, Mattson MP, Ingram DK, Weng NP. A link between maze learning and hippocampal expression of neuroleukin and its receptor gp78. J Neurochem. 2002;80(2):354-361. [Abs]

  40. Mattson MP. Accomplices to neuronal death. Nature. 2002;415(6870):377-379.

  41. Mattson MP. Brain evolution and lifespan regulation: conservation of signal transduction pathways that regulate energy metabolism. Mech Ageing Dev. 2002;123(8):947-953. [Abs]

  42. Mattson MP. Contributions of mitochondrial alterations, resulting from bad genes and a hostile environment, to the pathogenesis of Alzheimer's disease. Int Rev Neurobiol. 2002;53:387-409.

  43. Mattson MP. Involvement of superoxide in pathogenic action of mutations that cause Alzheimer's disease. Methods Enzymol. 2002;352:455-474.

  44. Mattson MP. Neurogenetics: white matter matters. Trends Neurosci. 2002;25(3):135-136.

  45. Mattson MP. Optic nerve requires tumor gene. Trends Neurosci. 2002;25:286-287.

  46. Mattson MP. Oxidative stress, perturbed calcium homeostasis, and immune dysfunction in Alzheimer's disease. J Neurovirol. 2002;8(6):539-50. [Abs]

  47. Mattson MP. Return from deafness. Trends Neurosci. 2002;25:231.

  48. Mattson MP. SDF1-CXCR4 and hippocampal morphogenesis. Trends Neurosci. 2002;25: 548-549.

  49. Mattson MP. Shock protein abducted in ALS. Trends. Neurosci. 2002;25:445.

  50. Mattson MP, Chan SL, Duan W. Modification of brain aging and neurodegenerative disorders by genes, diet, and behavior. Physiol Rev. 2002;82(3):637-672. [Abs]

  51. Mattson MP, Duan W, Chan SL, Cheng A, Haughey N, Gary DS, Guo Z, Lee J, Furukawa K. Neuroprotective and neurorestorative signal transduction mechanisms in brain aging: modification by genes, diet and behavior. Neurobiol Aging. 2002;23(5):695-705. [Abs]

  52. Mattson MP, Duan W, Maswood N. How does the brain control lifespan? Ageing Res Rev. 2002;1(2):155-165. [Abs]

  53. Mattson MP, Kruman II, Duan W. Folic acid and homocysteine in age-related disease. Ageing Res Rev. 2002;1(1):95-111. [Abs]

  54. Mattson MP, Liu D. Energetics and oxidative stress in synaptic plasticity and neurodegenerative disorders. Neuromolecular Med. 2002;2(2):215-231. [Abs]

  55. Mattson MP, Mattson EP. Amyloid peptide enhances nail rusting: novel insight into mechanisms of aging and Alzheimer's disease. Ageing Res Rev. 2002;1(3):327-330. [Abs]

  56. Mattson MP, Zhang P, Fu W. Assessing the involvement of telomerase in stem cell biology. Methods Mol Biol. 2002;198:125-136.

  57. Mayer-Proschel M, Liu Y, Xue H, Wu Y, Carpenter M,Rao MS. Human neural precursor cells- Culture and in vitro characterization. Clinical Neuroscience Research 2002;2:58-69.

  58. Milhavet O, Martindale JL, Camandola S, Chan SL, Gary DS, Cheng A, Holbrook NJ, Mattson MP. Involvement of Gadd153 in the pathogenic action of presenilin-1 mutations. J Neurochem. 2002;83(3):673-681. [Abs]

  59. Mujtaba T, Han SS, Fischer I, Sandgren EP, Rao MS. Stable expression of the alkaline phosphatase marker gene by neural cells in culture and after transplantation into the CNS using cells derived from a transgenic rat. Exp Neurol. 2002;174(1):48-57. [Abs]

  60. Mujtaba T, Rao MS. Isolation of lineage-restricted neural precursors from cultured ES cells. Methods Mol Biol. 2002;185:189-204.

  61. Pedersen WA, Chan SL, Zhu H, Abdur-Rahman LA, Verdi JM, Mattson MP. Numb isoforms containing a short PTB domain promote neurotrophic factor-induced differentiation and neurotrophic factor withdrawal-induced death of PC12 Cells. J Neurochem. 2002;82(4):976-986. [Abs]

  62. Pedersen WA, Wan R, Zhang P, Mattson MP. Urocortin, but not urocortin II, protects cultured hippocampal neurons from oxidative and excitotoxic cell death via corticotropin-releasing hormone receptor type I. J Neurosci. 2002;22(2):404-412. [Abs]

  63. Perry T, Greig NH. The glucagon-like peptides: a new genre in therapeutic targets for intervention in Alzheimer's disease. J Alzheimers Dis. 2002;4(6):487-496. [Abs]

  64. Perry T, Haughey NJ, Mattson MP, Egan JM, Greig NH. Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1 and exendin-4. J Pharmacol Exp Ther. 2002;302(3):881-888. [Abs]

  65. Perry T, Lahiri DK, Chen D, Zhou J, Shaw KT, Egan JM, Greig NH. A novel neurotrophic property of glucagon-like peptide 1: a promoter of nerve growth factor-mediated differentiation in PC12 cells. J Pharmacol Exp Ther. 2002 ;300(3):958-966. [Abs]

  66. Richard IH, Justus AW, Greig NH, Marshall F, Kurlan R. Worsening of motor function and mood in a patient with Parkinson's disease after pharmacologic challenge with oral rivastigmine. Clin Neuropharmacol. 2002;25(6):296-299. [Abs]

  67. Rogers JT, Randall JD, Cahill CM, Eder PS, Huang X, Gunshin H, Leiter L, McPhee J, Sarang SS, Utsuki T, Greig NH, Lahiri DK, Tanzi RE, Bush AI, Giordano T, Gullans SR. An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcript. J Biol Chem. 2002;277(47):45518-45528. [Abs]

  68. Rogers JT, Randall JD, Eder PS, Huang X, Bush AI, Tanzi RE, Venti A, Payton SM, Giordano T, Nagano S, Cahill CM, Moir R, Lahiri DK, Greig N, Sarang SS, Gullans SR. Alzheimer's disease drug discovery targeted to the APP mRNA 5'untranslated region. J Mol Neurosci. 2002;19(1-2):77-82. [Abs]

  69. Sambamurti K, Greig NH, Lahiri DK. Advances in the cellular and molecular biology of the beta-amyloid protein in Alzheimer's disease. Neuromolecular Med. 2002;1(1):1-31. [Abs]

  70. Tomac AC, Agulnick AD, Haughey N, Chang CF, Zhang Y, Backman C, Morales M, Mattson MP, Wang Y, Westphal H, Hoffer BJ. Effects of cerebral ischemia in mice deficient in Persephin. Proc Natl Acad Sci USA. 2002;99(14):9521-9526. [Abs]

  71. Utsuki T, Shoaib M, Holloway HW, Ingram DK, Wallace WC, Haroutunian V, Sambamurti K, Lahiri DK, Greig NH. Nicotine lowers the secretion of the Alzheimer's amyloid beta-protein precursor that contains amyloid beta-peptide in rat. J Alzheimers Dis. 2002;4(5):405-415. [Abs]

  72. Van Ess PJ, Mattson MP, Blouin RA. Enhanced induction of cytochrome P450 enzymes and CAR binding in TNF (p55(-/-)/p75(-/-)) double receptor knockout mice following phenobarbital treatment. J Pharmacol Exp Ther. 2002;300(3):824-830. [Abs]

  73. Van Ess PJ, Pedersen WA, Culmsee C, Mattson MP, Blouin RA. Elevated hepatic and depressed renal cytochrome P450 activity in the Tg2576 transgenic mouse model of Alzheimer's disease. J Neurochem. 2002;80(4):571-578. [Abs]

  74. Van Ess PJ, Poloyac S, Mattson MP, Blouin RA. Blunted induction of hepatic CYP4A in TNF (p55-/-/p75-/-) double receptor knockout mice following clofibrate treatment. Pharm Res. 2002;19(5):708-712.

  75. Wang Y, Mattson MP, Furukawa K. Endoplasmic reticulum calcium release is modulated by actin polymerization. J Neurochem. 2002;82(4):945-952. [Abs]

  76. Wolkow CA. Life span: getting the signal from the nervous system. Trends Neurosci. 2002;25(4):212-216. [Abs]

  77. Wolkow CA, Munoz MJ, Riddle DL, Ruvkun G. Insulin receptor substrate and p55 orthologous adaptor proteins function in the Caenorhabditis elegans daf-2/insulin-like signaling pathway. J Biol Chem. 2002;277(51):49591-49597. [Abs] - [Full Text]

  78. Wu YY, Mujtaba T, Han SS, Fischer I, Rao MS. Isolation of a glial-restricted tripotential cell line from embryonic spinal cord cultures. Glia. 2002;38(1):65-79. [Abs]

  79. Wu YY, Mujtaba T, Rao MS. Isolation of stem and precursor cells from fetal tissue. Methods Mol Biol. 2002;198:29-40.

  80. Yu QS, Zhu X, Holloway HW, Whittaker NF, Brossi A, Greig NH. Anticholinesterase activity of compounds related to geneserine tautomers. N-Oxides and 1,2-oxazines. J Med Chem. 2002;45(17):3684-3691. [Abs]

  81. Zhu X, Yu QS, Cutler RG, Culmsee CW, Holloway HW, Lahiri DK, Mattson MP, Greig NH. Novel p53 inactivators with neuroprotective action: syntheses and pharmacological evaluation of 2-imino-2,3,4,5,6,7-hexahydrobenzothiazole and 2-imino-2,3,4,5,6,7-hexahydrobenzoxazole derivatives. J Med Chem. 2002;45(23):5090-5097. [Abs]

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