Modeling and Mining Cancer Genomes (NIH-Only) |
|
|---|---|
|
|
|
| Launch in standalone player | |
| Air date: | Tuesday, May 08, 2007, 8:30:00 AM |
| Category: | NCI CCR Grand Rounds (NIH Only) |
| Runtime: | 60 minutes |
| NLM Title: | Modeling and mining cancer genomes [electronic resource] / Ronald DePinho. |
| Series: | Center for Cancer Research--National Cancer Institute grand rounds |
| Author: | De Pinho, Ronald A. National Institutes of Health (U.S.) |
| Publisher: | [Bethesda, Md. : National Institutes of Health, 2007] |
| Other Title(s): | Center for Cancer Research--National Cancer Institute grand rounds |
| Abstract: | (CIT): Center for Cancer Research - National Cancer Institute Grand Rounds. Dr. Ronald A. DePinho is currently Professor of Medicine and Genetics at Harvard Medical School, Director for the Center for Applied Cancer Science, and a member of the Department of Medical Oncology at the Dana Farber Cancer Institute. He holds the coveted American Cancer Society Research Professorship. Dr. DePinho has been a leader in the use of the mouse to dissect the molecular mechanisms and biological processes governing the genesis and maintenance of tumorigenesis. His studies on the Myc oncoprotein have led to insights into how physical and functional interactions among members of the Myc superfamily (Myc, Max and Mad) regulate the growth and development of normal and neoplastic cells. The demonstration that Mad family members act to repress transcription and suppress cancer in vivo, along with his co-discovery of the mSin3 co-repressor complex and its link to regulators of chromatin architecture, have defined a mechanistically distinct tumor suppressor pathway. His laboratory has explored and defined the functional relationship between Rb and p53 pathways, particularly p16INK4a and p19ARF, have delineated an intimate link between pathways that control cellular senescence and those that regulate cell cycle entry or cell survival. Dr. DePinho and his colleagues have also led efforts to understand the role of telomerase in cancer, development and aging, and how telomere dynamics inter-relate to DNA damage and recombination pathways. More recently, he and his colleagues have constructed inducible cancer models that permit an in vivo analysis of the complex symbiotic host-tumor cell communications required for tumor maintenance. Finally, Dr. DePinho has launched a new academic initiative at Harvard, the Center for Applied Cancer Science, whose mission is to translate basic science discoveries into drug development endpoints. |
| Subjects: | Aging Disease Models, Animal Genome Neoplasms--etiology Neoplasms--genetics |
| Publication Types: | Government Publications Lectures |
| NLM Classification: | QZ 200 |
| NLM ID: | 101308599 |
| CIT File ID: | 13809 |
| CIT Live ID: | 5900 |
| Permanent link: | http://videocast.nih.gov/launch.asp?13809 |