Laboratory of Functional and Molecular Imaging - Division of Intramural Research

 Alan P.  Koretsky  Ph.D., Senior Investigator

Dr. Koretsky received his S.B. degree from the Massachusetts Institute of Technology and Ph.D. from the University of California at Berkeley. He performed postdoctoral work in the NHLBI at NIH studying regulation of mitochondrial metabolism using optical and NMR techniques. Dr. Koretsky spent twelve years on the faculty in the Department of Biological Sciences at Carnegie Mellon University where he was the Eberly Professor of Structural Biology and Chemistry. In summer 1999, he moved to NINDS as Chief of the Laboratory of Functional and Molecular Imaging and Director of the NIH MRI Research Facility. Dr. Koretsky's laboratory is interested in two main areas. They are actively developing novel imaging techniques to visualize brain function and study the regulation of cellular energy metabolism combining molecular genetics with non-invasive imaging tools.

Laboratory Staff

Kevin  Bennett, Ph.D. IRTA Fellow  301-402- 9709
Kai-Hsiang Chuang, Ph.D. Postdoctoral Fellow  301-594- 7314
Richard Conroy, Ph.D. Guest Researcher  301-594- 7310
Steve Dodd, Ph.D. Research Fellow  301-402- 0389
Artem Goloshevsky, Ph.D. Research Fellow  301-435- 2146
Tom  Hu, Ph.D. Special Volunteer  301-402- 1329
Mary Kiganda, M.S. Biologist  301-435- 7945
Galit Pelled, Ph.D. IRTA Fellow  301-451- 9936
Erik Shapiro, Ph.D. Special Volunteer  301-594- 7311
Kathy  Sharer,  Research Assistant  301-402- 9652
James Sumner, Ph.D. IRTA Fellow  301-594- 0365
Jason Tucciarone, B.S. Post baccalaureate Fellow  301-435- 2148
Carolyn Wu, Ph.D. Research Fellow  301-451- 9913

Research Interests

The Functional and Molecular Imaging Section has two major research interests. One is to develop novel functional and molecular imaging techniques to study brain structure and function. Emphasis is on MRI but some optical imaging is performed as well. Current areas of interest are to extend spatial resolution and understand the relation of functional MRI to neuronal architecture. New imaging tools are being developed to image calcium influx and gene expression non-invasively in the mouse brain.

Selected Recent Publications

K. Chuang, A.P. Koretsky
Improved Neuronal Tract Tracing Using Manganese Enhanced Magnetic Resonance Imaging with Fast T1 Mapping - Magnetic Resonance in Medicine  55 604-611 2006

S.D. Keilholz, A.C. Silva, M. Raman, H. Merkle, A.P. Koretsky
BOLD and CBV-Weighted Functional Magnetic Resonance Imaging of the Rat Somatosensory System - Magnetic Resonance in Medicine  55 316-324 2006

I. Aoki, Y. Takahashi, K. Chuang, A.C. Silva, T. Igarashi, C. Tanaka, R.W. Childs, A.P. Koretsky
Cell Labeling for Magnetic Resonance Imaging with the T1 Agent Manganese Chloride - NMR in Biomedicine  19 50-59 2006

O. Rodriguez, S. Fricke, C. Chien, L. Dettin, J. Vanmeter, E.M. Shapiro, H. Dai, M. Casimiro, L. Lleva, J. Dagata, M.D. Johnson, M.P. Lisanti, A.P. Koretsky, C. Albanese
Contrast-Enhanced in Vivo Imaging of Breast and Prostate Cancer Cells by MRI - Cell Cycle  5 113-119 2006

E.M. Shapiro, K. Sharer, Skrtic, A.P. Koretsky
In Vivo Detection of Single Cells By MRI - Magnetic Resonance in Medicine  55 242-249 2006

J.H. Duyn, P. van Gelderen, S.L. Talagala, A.P. Koretsky, J.A. de Zwart
Technological Advances in MRI Measurement of Brain Perfusion - Journal of Magnetic Resonance Imaging  22 751-753 2005

Selected Earlier Publications

Contact Information

Laboratory of Functional and Molecular Imaging, NINDS Building 10, Room B1D728  10 Center Drive, MSC 1065   Bethesda MD  20892-1065

Telephone: 301-402- 9659 (office), 301- 402-9659 (laboratory), 301-480- 2558 (fax), Email: koretskya@ninds.nih.gov