Phosphoinositide 3-Kinase Pathway and Human Disease |
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| Launch in standalone player | |
| Air date: | Wednesday, February 09, 2005, 3:00:00 PM |
| Category: | Wednesday Afternoon Lectures |
| Description: | Phosphoinositide 3-kinase (PI3K) is activated by a host of hormones and growth factors and produces membrane bound lipid second messengers that are implicated in complex cellular events such as cell survival, cell growth, cell cycle entry and chemotaxis, based on ex-vivo experiments. We have used a variety of approaches to map protein kinase pathways upstream and downstream of PI3K. In addition, we have manipulated genes in the mouse to assess the role of PI3K and downstream responses in normal development, in insulin signaling and in cancers. These studies have revealed a tightly regulated and highly conserved signaling network, perturbations of which can result in a wide variety of diseases, including cancers, tuberous sclerosis and type 2 diabetes.
For more information, visit http://www.fas.harvard.edu/%7Ebiophys/Lewis_Cantley.htm WALS |
| Author: | Lewis Cantley, Ph.D., Harvard Institutes of Medicine |
| Runtime: | 60 minutes |
| Download: | Download
Video How to download a Videocast |
| CIT File ID: | 12445 |
| CIT Live ID: | 3441 |
| Permanent link: | http://videocast.nih.gov/launch.asp?12445 |