Clinical Trials
Bipolar Disorder (Manic-Depressive Illness)
Featured Studies
Featured studies include only those currently recruiting participants. They are listed according to the date they were added to the ClinicalTrials.gov registry, with the most recent studies appearing first.
- Double-Blind Placebo-Controlled Trial of Riluzole in Pediatric Bipolar Disorder.
Interventional study. Objective: To test the efficacy of riluzole in youth with bipolar disorder Study population: Youth, ages 9-17, with DSM-IV bipolar disorder, who have failed to respond to two adequate trials of medication, one with an atypical antipsychotic medication, and the second with either a mood stabilizing medication or a second atypical antipsychotic medication. Ages 9-17. Location in Bethesda, MD.
- Customized Medication Adherence Enhancement for Treating Adults With Bipolar Disorder.
Interventional study. In this study, patients with bipolar disorder who do not take their medications as prescribed will receive specialized education and therapy treatment to determine whether the specialized treatment is effective in helping patients to take their medications consistently. Ages 18 and over. Location in Cleveland, OH.
- Identifying Predictors of Bipolar Disorder Relapse During Pregnancy and the Postpartum Period.
Evaluation study. This study will evaluate pregnant women who have bipolar disorder to gain a better understanding of risk factors for bipolar disorder relapse during pregnancy and the postpartum period. Ages 18-45. Location in Atlanta, GA.
- Effectiveness of Lithium Plus Optimized Medication in Treating People With Bipolar Disorder.
Interventional study. This study will evaluate whether lithium included as part of optimized medication treatment improves overall level of illness, symptoms of mania and depression, and quality of life in people with bipolar disorder. Ages 18-80. Locations in Stanford, CA; Boston, MA; Cleveland, OH; Philadelphia, PA; Pittsburgh, PA; San Antonio, TX.
- Safety and Effectiveness of Antidepressant Therapy in Treating Bipolar Type II Major Depression.
Interventional study. This study will compare the safety and effectiveness of antidepressant therapy versus mood stabilizing therapy in treating people with bipolar type II major depression. Ages 18 and over. Location in Philadelphia, PA.
- FMRI Study of Brain Response Before and After Lithium Treatment in People With Bipolar Disorder.
Interventional study. This study will assess the effects of bipolar disorder on brain activity and will determine if medication changes the brain activity in people with bipolar disorder. Ages 18-60. Location in Indianapolis, IN.
- Effectiveness of Cognitive Behavioral Therapy for Treating Depression in People With Bipolar I Disorder.
Interventional study. This study will compare the effectiveness of cognitive behavioral therapy versus supportive psychotherapy in decreasing depression in people with bipolar disorder. Ages 18-64. Location in Boston, MA.
- Interpersonal and Social Rhythm Therapy for Adolescents With Bipolar Disorder.
Interventional study. This study will evaluate the effectiveness of interpersonal and social rhythm therapy in treating adolescents with a bipolar spectrum disorder Ages 12-18. Location in Seattle, WA.
- Development of Magnetic Resonance Imaging Techniques for Studying Mood and Anxiety Disorders.
Evaluation study. This study is intended to help develop new MRI imaging techniques for studying mood and anxiety disorders. Ages 18-50. Location in Bethesda, MD.
- Measuring Smoking Behavior in People With Schizophrenia and Bipolar Disorder.
Evaluation study. This study will evaluate the differences in smoking behavior, nicotine intake, and nicotine boost among people with schizophrenia, bipolar disorder, or no mental illness. Ages 18-75. Location in New Brunswick, NJ.
- The Antidepressant Efficacy of the Anticholinergic Scopolamine.
Interventional study. A previous study showed that the intravenous administration of scopoalmine produces antidepressant effects. Ages 18-55. Location in Bethesda, MD.
- Early Detection and Prevention of Mood Disorders in Children of Parents With Bipolar Disorder.
Interventional study. This study will develop strategies for early detection and prevention of mood disorders and associated impairment in adolescent children of parents with bipolar disorder. Ages 12-17. Location in New York, NY.
- Effectiveness of Family-Focused Treatment Plus Pharmacotherapy for Bipolar Disorder in Adolescents.
Interventional study. This study will evaluate the effectiveness of family-focused treatment (FFT) plus pharmacotherapy in treating adolescents with bipolar disorder. Ages 13-17. Locations in Boulder, CO; Cincinnati, OH; Pittsburgh, PA.
- Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder.
Interventional study. This study will examine whether mitochondrial function is impaired in patients with bipolar disorder. Ages 18-65. Location in Bethesda, MD.
- Impact of Pregnancy and the Postpartum Period on Women With Bipolar Disorder.
Evaluation study. This study will determine the risk factors for a depressive, manic, or hypomanic episode during pregnancy and the postpartum period in women with bipolar disorder. Ages 18-45. Location in Boston, MA.
- Bipolar II Depression: Lithium, SSRI, or the Combination.
Interventional study. This study will compare the safety and effectiveness of a mood stabilizing medication, an antidepressant medication, and a combination of both medications to treat symptoms of bipolar type II depression. Ages 18-65. Locations in Los Angeles, CA; Palo Alto, CA; Mason, OH.
- Treatment of Bipolar Mania in Older Adults.
Interventional study. This study will compare the benefits and side effects of lithium and divalproex in the treatment of older adults with bipolar mania. Ages 60 and over. Locations in Flowood, MS; Durham, NC; White Plains, NY; Cleveland, OH; Toronto, ON; Philadelphia, PA; Pittsburgh, PA; Houston, TX.
- Maintenance Treatment of Bipolar Depression.
Interventional study. This study will compare two different antidepressant treatment regimens to determine which is more effective in reducing symptoms of bipolar depression. Ages 18 and over. Location in San Antonio, TX.
- Reproductive Function and Mood in Women With Bipolar Disorder.
Evaluation study. This study will determine the effect of medication for bipolar disorder on the reproductive function and whether mood changes occur during the menstrual cycle in women with bipolar disorder. Ages 18-40. Location in Stanford, CA.
- Dopamine Receptor Imaging in Mood Disorders.
Evaluation study. This study seeks to increase the understanding of dopamine receptor function in the brain during major depressive disorder and bipolar depression, as well as genetic changes that may be behind changes in those receptors' actions. Ages 18-55. Location in Bethesda, MD.
- Rapid Antidepressant Effects of Ketamine in Major Depression.
Interventional study. This study examines whether Ketamine can cause a rapid-next day antidepressant effect in patients with Major Depression/Bipolar Disorder . Ages 18-65. Location in Bethesda, MD.
- Treatment of Early Age Mania.
Interventional study. This study will evaluate the effectiveness of the medications, lithium (Eskalith®), valproate (Depakote®), and risperidone (Risperdal®) in treating children and adolescents with bipolar disorder or symptoms of mania. Ages 6-15. Locations in Washington, DC; Baltimore, MD; St. Louis, MO; Pittsburgh, PA; Galveston, TX.
- Cholinergic Modulation of Condition and Emotion in Mood Disorders: Functional Neuroimaging Studies.
Interventional study. This study looks at the role of a specific brain chemical system in the mood and attention symptoms seen in major depression and bipolar disorders using functional brain imaging. Ages 18-45. Location in Bethesda, MD.
- Riluzole to Treat Depression in Bipolar Disorder.
Interventional study. This study examines if Riluzole, (FDA approved for ALS), will improve symptoms of depression in Bipolar Disorder. Ages 18-70. Location in Bethesda, MD.
- Brain Imaging in Depression.
Evaluation study. The purpose of this study is to use brain imaging technology to examine the role of certain brain receptors and the nervous system chemical acetylcholine in major depression. Ages 18-45. Location in Bethesda, MD.
- Examination of Brain Serotonin Receptors in Patients With Mood Disorders.
Evaluation study. The purpose of this study is to evaluate the function of certain brain chemicals and receptors in patients with mood disorders. Ages 18-60. Location in Bethesda, MD.
- Studies of Brain Function and Course of Illness in Pediatric Bipolar Disorder.
Evaluation study. We study the course of child bipolar illness and how brain function differs between youth with bipolar disorder, those 'at-risk,' and healthy volunteers. Ages 7-17. Location in Bethesda, MD.
- Child & Adolescent Bipolar Disorder Brain Imaging and Treatment Study.
Evaluation study. The National Institute of Mental Health is seeking boys and girls ages 6 to 17 with bipolar disorder who are not doing well on their current medication(s) to participate in a research study. Ages 3-17. Locations in Washington, DC; Boston, MA; Baltimore, MD; New Hyde Park, NY.
- Magnetic Resonance Imaging (MRI) of Neuropsychiatric Patients and Healthy Volunteers.
Evaluation study. The purpose of this study is to use brain imaging technology to compare differences in brain structure, chemistry, and functioning in individuals with brain and mental disorders compared to healthy volunteers. Ages 18 and over. Location in Bethesda, MD.
- Evaluation of the Genetics of Bipolar Disorder.
Evaluation study. This study looks to identify genes that may affect a person's chances of developing bipolar disorder (BP) and related conditions. Ages 18 and over. Locations in La Jolla, CA; Orange, CA; Washington, DC; Iowa City, IA; Chicago, IL; Indianapolis, IN; Louisville, KY; Baltimore, MD; Detroit, MI; St. Louis, MO; Stonybrook, NY; Philadelphia, PA.
- Brain Tissue Collection for Neuropathological Studies.
Evaluation study. The purpose of this study is to collect and study the brain tissue of deceased individuals to learn more about the nervous system and mental disorders. Locations in Washington, DC; Bethesda, MD; Fairfax, VA.
Search ClinicalTrials.gov for other NIH studies on Bipolar Disorder (Manic-Depressive Illness).
