APPENDIX A: REVIEW GROUP PROCESS

Meeting Dates The developmental therapeutics program review group met together in Bethesda or Rockville, Maryland in the following dates:

September 29-30, 1997
December 16, 1997		March 16, 1998
May 11, 1998

Subcommitte Process and Meeting Dates

The Review Group formed five subcommittees, each of which took primary responsibility for a set of issues identified by the full Review Group. Although the subcommittees met separately with ad hoc members to develop recommendations, the entire Review Group discussed issues addressed by the subcommittees. In addition, the Chair visited the NCI Developmental Therapeutics Program in Frederick, Maryland on February 20, 1998.

Subcommittee on Small Molecule Diversity and Screening Technology

The Subcommittee on Small Molecule Diversity and Screening Technology met in Boston, Massachusetts on October 28, 1997.

Chairman:Jon Clardy, Cornell University
Members:Susan Band Horwitz, Albert Einstein College of Medicine
David Kingston, Virginia Polytechnic Institute & State University
Cedric Long, National Cancer Institute
Stuart Schreiber, Howard Hughes Medical Institute, Harvard University
Christopher Walsh, Harvard Medical School

Subcommittee on Structural Inventory of Potential Drug Targets

The Subcommittee on Structural Inventory of Potential Drug Targets met in San Francisco, California on November 18, 1997.

Chairman:Gregory L. Verdine, Harvard University
Members:David Eisenberg, University of California, Los Angeles
Russell Hirsch, General Partner, Mayfield Fund
Susan Band Horwitz, Albert Einstein College of Medicine
Marvin Kalt, National Cancer Institute
Frank McCormick, University of California-San Francisco
Garth Powis, Arizona Cancer Center
Robert Tjian, Howard Hughes Medical Institute, University of California, Berkeley
J. Ernest Villafranca, Agouron Pharmaceuticals, Inc.
James Wells, Genentech, Inc.

Subcommittee on Animal Models

The Subcommittee on Animal Models met in Boston, Massachusetts on November 17, 1997.

Chairman:Allen Oliff, Merck Research Laboratories
Members:Susan Band Horwitz, Albert Einstein College of Medicine
Tyler Jacks, Massachusetts Institute of Technology
David Livingston, Dana-Farber Cancer Institute
Cedric Long, National Cancer Institute
Alex Matter, Novartis Pharma AG
Edward Sausville, National Cancer Institute

Subcommittee on Pharmacology and Toxicology, and Formulation

The Subcommittee on Pharmacology and Toxicology, and Formulation met in New York, New York on October 27, 1997 and in Bethesda, Maryland on November 10, 1997.

Chairman:John S. Lazo, University of Pittsburgh
Members:Joseph R. Bertino, Memorial Sloan-Kettering Cancer Center
Kenneth R. Harrap, Weston & Harrap Consulting
Susan Band Horwitz, Albert Einstein College of Medicine
Cedric Long, National Cancer Institute

Subcommittee on Biologics

The Subcommittee on Biologics met in San Francisco, California. on December 12, 1997.

Chairman:Drew Pardoll, Johns Hopkins University School of Medicine
Members:James Allison, University of California - Berkeley
Phil Greenberg, University of Washington School of Medicine
Cedric Long, National Cancer Institute
Ellen Vitetta, University of Texas Southwestern School of Medicine