Dynamics of macromolecular complexes in living cells: Multiplex imaging of signaling activities, genetically encoded protein uncaging, and RapR-FAK |
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| Launch in standalone player | |
| Air date: | Friday, May 23, 2008, 10:00:00 AM |
| Category: | Proteomics |
| Runtime: | 75 minutes |
| NLM Title: | Dynamics of macromolecular complexes in living cells : multiplex imaging of signaling activities, genetically encoded protein uncaging, and rapR-FAK [electronic resource] / Klaus Hahn. |
| Series: | Multiplex imaging of signaling activities, genetically encoded protein uncaging, and rapR-FAK |
| Author: | Hahn, Klaus M. National Institutes of Health (U.S.) |
| Publisher: | [Bethesda, Md. : National Institutes of Health, 2008] |
| Other Title(s): | Multiplex imaging of signaling activities, genetically encoded protein uncaging, and rapR-FAK |
| Abstract: | (CIT): This talk will describe approaches to study and manipulate multiple nodes of a signaling pathway in living cells, revealing unexpected relationships between Rho family GTPases in motility. New methods for spatially and temporally controlled manipulation of protein activity will be described, including genetically encoded caged Rac, and Fak activated by drug treatment. These approaches may provide generally applicable tools to study signaling pathways in living cells. |
| Subjects: | Cell Movement Signal Transduction rho GTP-Binding Proteins |
| Publication Types: | Government Publications Lectures |
| NLM Classification: | QU 375 |
| NLM ID: | 101475736 |
| CIT File ID: | 14522 |
| CIT Live ID: | 6787 |
| Permanent link: | http://videocast.nih.gov/launch.asp?14522 |