Methods for the Identification and Use of Compounds Suitable for the Treatment of Drug Resistant Cells
Description of Invention:
There is an important need to overcome cancer multiple drug resistance (MDR). ATP-binding cassette (ABC) transporters are a family of transporter proteins that contribute to drug resistance via ATP-dependent drug efflux pumps. Accordingly, based on the expression profile of 48 ABC transporters in sixty (60) cell lines, the present invention provides a method to identify (1) drugs that retain action in cells expressing MDR proteins, (2) compounds that reduce MDR by interfering with the efflux pumps. In addition, the invention describes a method to identify compounds whose antiproliferative effect is potentiated by the ABCB1/MDR1 transporter. These compounds might avoid the well-documented side-effects observed in clinical trials of "classical" MDR1 inhibitors and may serve as leads for development of novel anti-cancer agents to treat resistant disease.
Inventors:
Gergely Szakacs et al. (NCI)
Patent Status:
DHHS Reference No. E-075-2004/0 --
U.S. Provisional Application No. 60/580,397 filed 18 Jun 2004
DHHS Reference No. E-075-2004/1 --
U.S. Provisional Application No. 60/602,640 filed 19 Aug 2004
DHHS Reference No. E-075-2004/2 --
PCT Application No. PCT/US2005/21253 filed 17 Jun 2005
U.S. Patent Application No. 11/629,233 filed 07 Dec 2006
Portfolios: Cancer
Cancer -Diagnostics Cancer -Therapeutics Cancer -Research Materials
For Additional Information Please Contact: David A. Lambertson Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd, Suite 325
Rockville, MD 20852-3804
Phone: (301)435-4632
Email: lambertsond@mail.nih.gov
Fax: (301) 402-0220
