Cell Matrix Receptor System And Use In Cancer Diagnosis And Management
Description of Invention:
A method of diagnosis and management of cancer, particularly breast cancer, is provided. The method involves interfering with the mechanism by which tumor cells adhere to the various membranes and tissues of the body, enabling replication, using cell receptors specific for the laminin molecule. The laminin molecule normally adheres to collagen IV of the membranes and tissues. The novel laminin molecule disclosed binds the cell receptor of the tumor cell because it has an affinity for the receptor but it does not have an affinity for collagen IV which is part of the membranes and tissues of the body.
Other applications include possible burn therapy through the promotion of adhesion and growth of epithelial cells, which form the covering of most internal organs and outer surface layers of skin.
Secondly, this invention provides a method for evaluating the effectiveness of chemotherapeutic agents designed to affect the receptor in cancer cells. The invention discloses a kit for detecting the presence of metastasizing cancer cells having this cell receptor. A method of separation of metastatic cancer cells expressing the cell receptor from a mixed population of cells is also provided. Also provided is a method of detecting breast cancer using radiolabelled antibodies specific to the cell receptor.
Inventors:
LA Liotta NC Rao V Terranova (NCI)
Patent Status:
DHHS Reference No. E-093-1983/0 Licensing Status: This technology is no longer available for licensing.
Portfolios: Internal Medicine Cancer
Cancer -Diagnostics-In Vitro-MAb Based Cancer -Diagnostics-In Vivo-Conjugate Chemistry Cancer -Therapeutics-Biological Response Modifiers-Growth Factors Cancer -Diagnostics Cancer -Therapeutics Cancer -Research Materials Cancer -Other Internal Medicine-Therapeutics
For Additional Information Please Contact: Jennifer Wong
NIH Office of Technology Transfer
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Phone: (301)435-4633
Email: wongje@mail.nih.gov
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