Description of Invention:
Hyperintense acute reperfusion marker (HARM) is well correlated with reperfusion and is a precursor to or concomitant with reperfusion injury. The inventors have developed a novel technique of assessing injuries associated with ischemia, stroke, or reperfusion injury in a patient by administering a contract agent to the patient, acquiring a fluid-attenuated inversion-recovery (FLAIR) image, and observing the presence or absence of HARM on the acquired image. The technique can also be used to determine the effectiveness of a therapeutic protocol for the treatment or prevention of reperfusion injury in a patient that has previously suffered an ischemic event.
Inventors:
Steven Warach and Lawrence Latour (NINDS)
Relevant Publication:
This research has been described, in part, in Latour et al., “Early Blood-Brain Barrier Disruption in Human Focal Brain Ischemia,” Ann. Neurol. 2004 56:568-477.
Portfolios: Devices/Instrumentation
Devices/Instrumentation-Diagnostics-Physical Medicine Devices/Instrumentation-Diagnostics-Instruments Devices/Instrumentation-Diagnostics-Imaging Devices/Instrumentation-Diagnostics
For Additional Information Please Contact: Michael Shmilovich J.D.
NIH Office of Technology Transfer
6011 Executive Blvd, Suite 325
Rockville, MD 20852-3804
Phone: (301) 435-5019
Email: shmilovm@mail.nih.gov
Fax: (301) 402-0220
