Method for the Diagnosis and Treatment of Vascular Disease
Description of Invention:
Cardiovascular disease is a major health risk throughout the industrialized world. Atherosclerosis, the most prevalent of cardiovascular diseases, is the principal cause of heart attack, stroke, and gangrene of the extremities. It is also the principal cause of death in the United States.
This invention portrays a method for diagnosing decreased vascular function, detecting increased cardiovascular risk and diagnosing atherosclerosis. An embodiment includes assaying the number of endothelial progenitor cells and treating a subject with decreased vascular function by administering a therapeutically effective amount of endothelial progenitor cells.
Inventors:
Toren Finkel et al. (NHLBI)
Patent Status:
DHHS Reference No. E-037-2003/0 --
U.S. Provisional Application No. 60/426,545 filed 15 Nov 2002
DHHS Reference No. E-125-2003/0 --
U.S. Provisional Application No. 60/445,417 filed 05 Feb 2003
DHHS Reference No. E-037-2003/1 --
PCT Application No. PCT/US03/36317 filed 12 Nov 2003, which published as WO 2004/045517 on 03 Jun 2004
U.S. Patent Application No. 10/534,626 filed 11 May 2005
Relevant Publication: J.M. Hill, G. Zalos, J.P.J. Halcox, W.H. Schenke, M.A. Waclawiw, A.A. Quyyumi, and T. Finkel. Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. New Eng. J. Med. 348:593-600, Feb 13, 2003.
Portfolios: Internal Medicine
Internal Medicine-Diagnostics
For Additional Information Please Contact: Tara L. Kirby Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd, Suite 325
Rockville, MD 20852-3804
Phone: (301)435-4426
Email: tarak@mail.nih.gov
Fax: (301)402-0220
