A Metastasis Suppressor Gene on Human Chromosome 8 and Its Use in the Diagnosis, Prognosis, and Treatment of Cancer
Description of Invention:
The subject technology is directed to a gene on human chromosome 8 that suppresses metastasis of prostate cancer. The gene has been shown to suppress the metastatic ability of rat prostate cancer and is down-regulated in human prostate cancers from metastatic foci. Embodiments of the technology include gene therapy to prevent the metastasis of human cancer, in particular prostate cancer, use of the gene as a clinical marker in the diagnosis and prognosis of cancer, in particular prostate cancer, and the development of small molecules that mimic the effect of the gene product.
The present invention provides an isolated or purified nucleic acid molecule consisting essentially of a nucleotide sequence encoding the metastasis suppressor gene located at p21-p12 on human chromosome 8, which has been named Tey 1, or a fragment thereof comprising at least 455 contiguous nucleotides.
Inventors:
Naoki Nihei (NIEHS) J. Carl Barrett (NCI) Natalay Kouprina (NCI) Vladimir Larionov (NCI)
Patent Status:
DHHS Reference No. E-238-2001/0 --
U.S. Provisional Application No. 60/345,109 filed 21 Dec 2001
PCT Application No. PCT/US02/40998 filed 20 Dec 2002, which published as WO 03/060074 on 24 Jul 2003
U.S. Patent Application No. 10/499,515 filed 21 Jun 2004
Portfolios: Cancer
Cancer -Diagnostics Cancer -Therapeutics
For Additional Information Please Contact: Mojdeh Bahar J.D.
NIH Office of Technology Transfer
6011 Executive Blvd, Suite 325
Rockville, MD 20852-3804
Phone: (301)435-2950
Email: baharm@mail.nih.gov
Fax: (301) 402-0220
