Methods of Inducing Deacetylase Inhibitors to Promote Cell Differentiation and Regeneration
Description of Invention:
The present invention discloses a method of enhancing progenitor cell differentiation, including enhancing myogenesis, neurogenesis and hematopoiesis, by contacting a progenitor cell with an effective amount of a deacetylase inhibitor (DI). The progenitor cell can be part of cell culture, such as a cell culture used for in vitro or in vivo analysis of progenitor cell differentiation, or can be part of an organism, such as a human or other mammal. Contacting the progenitor cell with a DI can lead to enhancement of expression of terminal cell-type specific genes in the progenitor cell, such as enhancing expression of muscle-specific genes in myoblasts, and can lead to skeletal muscle hypertrophy. Administering a DI to a subject also can provide some prophylactic or therapeutic effect for inhibiting, preventing, or treating associated with a degeneration or loss of tissue. The DI can be administered to a subject as part of a pharmaceutical composition.
Inventors:
Vittorrio Sartorelli (NIAMS) et al.
Patent Status:
DHHS Reference No. E-353-2001/0 --
U.S. Provisional Application No. 60/335,705 filed 18 Oct 2001
DHHS Reference No. E-353-2001/1 --
U.S. Provisional Application No. 60/343,854 filed 25 Oct 2001
DHHS Reference No. E-353-2001/2 --
PCT Application No. PCT/US02/33570 filed 17 Oct 2002, which published as WO 03/033678 on 24 Apr 2003
U.S. Patent Application No. 10/492,901 filed 15 Apr 2004
For Additional Information Please Contact: Fatima Sayyid M.H.P.M.
NIH Office of Technology Transfer
6011 Executive Blvd, Suite 325
Rockville, MD 20852-3804
Phone: (301) 435-4521
Email: sayyidf@mail.nih.gov
Fax: (301) 402-0220
