Description of Invention:
The present invention relates to novel diagnostic methods for Herpes Simplex Virus Type 2 (HSV-2). HSV-2 infects approximately one fifth of adults in the United States and is the most common cause of genital ulceration. The invention relates to the detection of HSV-2 based on a transforming nucleic acid sequence and its protein product. This DNA sequence harbors the potential to induce the tumorigenic transformation of normal cells in in vitro and in vivo assays and thus will be useful as a means of prognostic evaluation in predicting the development of genital or cervical cancer. Current HSV-2 diagnostic tests relying on tedious viral culture and/or immunoassays that do not have the sensitivity and the specificity essential for diagnosis. Using PCR, the current invention will provide a superior method for viral detection and subtyping.
Application:
HSV-2 diagnostic
Inventors:
Joseph A. DiPaolo (NCI) et al.
Patent Status:
DHHS Reference No. E-091-1999/0 --
U.S. Patent 6,617,103 issued 09 Sep 2003
CA Application 2,259,657 filed 30 Jun 1997
Licensing Status: Available for non-exclusive or exclusive licensing.
Collaborative Research Opportunity:
The NCI Division of Basic Science is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize HSV-2 Diagnostic. Please contact Betty Tong, Ph.D. at 301-594-4263 or tongb@mail.nih.gov for more information.
For Additional Information Please Contact: Susan Ano Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd, Suite 325
Rockville, MD 20852-3804
Phone: (301) 435-5515
Email: anos@mail.nih.gov
Fax: (301) 402-0220
