Method for Non-Invasive Identification of Individuals at Risk for Diabetes
Description of Invention:
The invention is a non-invasive technique for the detection of ocular pathologies, including molecular changes associated with diabetes. Raman spectra emitted from an eye that is subject to a laser probe provides information regarding early markers of diabetes or diabetes-induced ocular pathologies. The invention compares spectra taken from the subject under study to spectra from a normal subject. Multivariate statistical methods are used to obtain predictive information based on the detected spectra, and to diagnose or predict the onset or stage of progression of diabetes-induced ocular pathology.
Inventors:
Anthony J. Durkin (FDA) Marwood N. Ediger (FDA) Michelle V. Chenault (FDA)
Patent Status:
DHHS Reference No. E-091-1998/0 --
U.S. Provisional Application No. 60/109,257 filed 19 Nov 1998
PCT Application No. PCT/US99/27360 filed 18 Nov 1999, which published as WO 00/28891 on 25 May 2000
U.S. Patent Application No. 09/856,186 filed 20 Mar 2002, which issued as U.S. Patent 6,721,583 on 13 Apr 2004
For Additional Information Please Contact: Michael Shmilovich J.D.
NIH Office of Technology Transfer
6011 Executive Blvd, Suite 325
Rockville, MD 20852-3804
Phone: (301) 435-5019
Email: shmilovm@mail.nih.gov
Fax: (301) 402-0220
