Stromal Cell Derived Factor-1 (SDF-1) And Method Of Use For Diagnostic
And Prognostic Indicator Or AIDS Pathogenesis
Description of Invention:
Stromal cell derived factor-1 (SDF-1) is the principal ligand for CXCR4 (a 7-
transmembrane G-coupled receptor) which, with CD4, provides an entry port for T-
tropic HIV-1, a variety that frequently develops in AIDS patients just prior to T-lymphocyte depletion. This invention is based on the discovery of a correlation between the presence of a mutation at one nucleotide position of the 3'untranslated region of the SDF1 gene and delayed progression to AIDS and death due to HIV infection. Based on this discovery, it is the object of the present invention to provide diagnostic and therapeutic approaches to treating HIV infection by diagnosing the mutation and down regulating the CXCR4 receptor with native or synthetic SDF-1.
Inventors:
C Winkler S O'Brien (NCI)
Patent Status:
DHHS Reference No. E-283-1997/0 Licensing Status: This technology is no longer available for licensing.
For Additional Information Please Contact: Sally Hu PhD MBA
NIH Office of Technology Transfer
6011 Executive Blvd, Suite 325
Rockville, MD 20852-3804
Phone: (301) 435-5606
Email: hus@mail.nih.gov
Fax: (301) 402-0220
