A Novel, Clinically Validated, Efficient and Non-Invasive In Vitro Diagnostic and Prognostic Test for Cancer
Description of Invention:
Cripto-1 (CR1) is a member of the epidermal growth factor (EGF)-related families of peptides and is involved in the development and progression of various human carcinomas. In particular, CR1 overexpression has been detected in 50-90% of carcinomas of the colon, pancreas, stomach, gallbladder, breast, lung, endometrium and cervix. Current methodologies of cancer detection, e.g. immunohistochemistry, can be time consuming, inconvenient and oftentimes, inaccurate, and therefore, a need exists for more efficient, reliable and less time consuming methods of detection. The invention relates to such a method of detection. Thus, this test could be used to more effectively screen and perhaps stage cancers. Additionally, should particular tumor cells, e.g. breast tumor cells, express a sufficiently high level of CR1, it may be possible to use the disclosed assay to detect and measure CR1 in human serum and/or plasma and possibly other physiological fluids.
Applications:
Antibody-mediated cancer therapeutics
Method for the detection and quantification of cripto-1 human milk, serum, plasma and other biological fluids using an ELISA-based protocol
Inventors:
Caterina Bianco (NCI) David S. Salomon (NCI)
C Bianco, C Wechselberger, A Ebert, NI Khan, Y Sun, DS Salomon. Identification of Cripto-1 in human milk. Breast Cancer Res Treat. 2001 Mar;66(1):1-7. [PubMed abs]
C Bianco, L Strizzi, M Mancino, A Rehman, S Hamada, K Watanabe, A De Luca, B Jones, G Balogh, J Russo, D Mailo, R Palaia, G D'Aiuto, G Botti, F Perrone, DS Salomon, N Normanno. Identification of cripto-1 as a novel serologic marker for breast and colon cancer. Clin Cancer Res. 2006 Sep 1;12(17):5158-5164. [PubMed abs]
Licensing Status: This technology is available for non-exclusive licensing.
Portfolios: Cancer
Cancer -Diagnostics
For Additional Information Please Contact: Michelle A. Booden Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd, Suite 325
Rockville, MD 20852-3804
Phone: (301)451-7337
Email: boodenm@mail.nih.gov
Fax: (301) 402-0220
