ARG, A Human Gene Related to but Distinct from ABL Proto-Oncogene
Description of Invention:
This patent relates to the identification, isolation and cloning of the gene ARG (abelson related gene) also known as ABL2. ARG/ABL2 is located on the long arm of chromosome 1 at 1q24-q25. It is a non-receptor tyrosine kinase. Recent work, by Iijima, et al. Blood 95(6): 2126-2131 (March 15, 2000) and Cazzaniga, et al. Blood 94(12):4370-4373 (December 15, 1999), has demonstrated that ABL2/ARG is a partner with the ETV6/TEL gene. ETV6/TEL, located on the short arm of chromosome 12 at 12p13 has previously been implicated in hematological disease, particularly leukemias, through chromosomal translocations. The fusion protein derived from this partnership between ETV6/TEL and ARG/ABL2 includes exons 1-5 of ETV6 (5' PNT region) and the 3' portion of ARG/ABL2 beginning with exon 1B or 2 which contains all of the functional domains of ARG/ABL2. This new work suggests that ARG plays a role in AML and possibly other leukemias.
Inventors:
GD Kruh (NCI) SA Aaronson (NCI)
Patent Status:
DHHS Reference No. E-336-1987/1 --
U.S. Patent 5,693,778 issued 02 Dec 1997
Relevant Publication: This work has been published at Kruh GD, et al. Science 234(4783):1545-8 (Dec 19, 1986) and Kruh GD, et al. PNAS, USA 87:5802 (Aug 1990).
Portfolios: Cancer
Cancer -Diagnostics-In Vitro-DNA Based Cancer -Diagnostics Cancer -Research Materials
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