A Method For Imaging Nicotinic Acetylcholinergic Receptors In The Brain Using Radiolabeled Pyridyl 7-Azabicycloheptanes
Description of Invention:
The current invention embodies the use of radiolabeled analogs of epibatidine to noninvasively image and quantify levels of nicotinic acetylcholine receptors in a living mammalian brain, using Positron Emission Tomography or other nuclear medicine methods. As nicotinic acetylcholine receptors have been implicated in various neuropathological and physiological disorders, including Alzheimer's disease, the invention may represent a powerful new method for the noninvasive diagnosis of Alzheimer's disease and other disorders. In addition, the method embodied in the invention may prove valuable for use in monitoring the progression of various disorders and in determining the efficacy of drug therapy protocols used in the treatment of these disorders.
Inventors:
ED London (NIDA) AS Kimes (NIDA) A Horti (NIDA) M Kassiou (NIDA) et al.
Patent Status:
DHHS Reference No. E-030-1996/0 --
U.S. Patent 5,726,189 issued 10 Mar 1998 U.S. Patent 5,969,144 issued 19 Oct 1999
Portfolios: Central Nervous System
Central Nervous System -Diagnostics-In Vivo Central Nervous System -Diagnostics
For Additional Information Please Contact: Michael Shmilovich J.D.
NIH Office of Technology Transfer
6011 Executive Blvd, Suite 325
Rockville, MD 20852-3804
Phone: (301) 435-5019
Email: shmilovm@mail.nih.gov
Fax: (301) 402-0220
