Description of Invention:
Rotaviruses are recognized as the single most important etiologic agent of severe diarrhea in both developed and non-developed countries. This invention embodies an attenuated rotavirus as a vaccine. The claims of the invention relate to the generation of a cold-adapted virus that is not efficient in replication at normal human body temperatures and therefore may be capable of stimulating an immune response without causing illness. In a limited clinical trial, administration of a cold-adapted rotavirus vaccine to 26 adults demonstrated that the vaccine was safe, attenuated, and was capable of inducing a virus-specific serologic response. This invention has been PCT filed on July 11, 1995.
Inventors:
Y Hoshino AZ Kapikian RM Chanock (NIAID)
For Additional Information Please Contact: Chekesha S. Clingman Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd, Suite 325
Rockville, MD 20852-3804
Phone: (301)435-5018
Email: clingmac@mail.nih.gov
Fax: (301) 402-0220
