Method And System For Multidimensional Localization And Rapid Magnetic Resonance Spectroscopic Imaging
Description of Invention:
A newly developed method and system for multidimensional localization and rapid magnetic resonance spectroscopic imaging allows for quicker, more accurate imaging of metabolites in biologic tissue. Nuclear magnetic resonance (NMR) techniques have long been used to obtain spectroscopic information about substances in order to reveal the substance's chemical composition. More recently, spectroscopic imaging techniques have been developed that combine magnetic resonance imaging (MRI) with NMR spectroscopic techniques, thus providing a spacial image of the chemical composition; however, previously available techniques for making such measurements have been hampered by limitations in prelocalization of samples due to long echo times as well as long data acquisition times. Most of these systems often generate spectral as well as spacial data due to the long echo times, and their localization techniques are not applicable to acquiring multiple-volume data from nuclei that have short T2 relaxation times. This new system circumvents these limitations by applying pulse sequence to a conventional MRI apparatus, which allows the rapid acquisition of data for generating spectroscopic images and greatly shortens the echo time. Spatial prelocalization of a volume of interest is achieved by providing a presuppression sequence before a stimulated echo (STE) sequence and a suppression sequence before the interval of the STE sequence.
Inventors:
S Posse (CC) D Le Bihan (CC)
Patent Status:
DHHS Reference No. E-223-1993/1 --
U.S. Patent 5,657,758 issued 19 Aug 1997
Related Technologies: DHHS Reference No. E-223-1993/0 --
U.S. Patent 5,709,208 issued 20 Jan 1998
U.S. Patent 5,879,299 issued 09 Mar 1999
For Additional Information Please Contact: Michael Shmilovich J.D.
NIH Office of Technology Transfer
6011 Executive Blvd, Suite 325
Rockville, MD 20852-3804
Phone: (301) 435-5019
Email: shmilovm@mail.nih.gov
Fax: (301) 402-0220
