Pigment Epithelium Derived Factor: Characterization of Its Novel Biological Activity and Sequences Encoding and Expressing the Protein
Description of Invention:
Pigment epithelium-derived factor (PEDF), a unique 50 kD protein secreted by retinal pigment epithelium (RPE) cells, has trophic activity. This invention describes the biological activity of PEDF, a method of enhancing neuron cell survival and a method of inhibiting glial cell proliferation, as well as purified antibodies to PEDF and an immunoassay. This technology can be used to develop therapeutics for the treatment of inflammatory, vascular, degenerative, and dystrophic diseases of the retina and central nervous system (CNS).
Potential Area of Application:
Alzheimer's disease
Huntington's disease
glutamate poisoning
Parkinson's disease
Main Advantage of Invention:
enhance neuronal cell survival
inhibit glial cell proliferation
Inventors:
GJ Chader (NEI) SP Becerra (NEI) JP Schwartz (NINDS) T Taniwaki (NINDS) Y Sugita (NINDS)
Patent Status:
DHHS Reference No. E-185-1992/1 --
U.S. Patent 5,840,686 issued 24 Nov 1998
DHHS Reference No. E-185-1992/4 --
PCT/US95/07201 filed 06 Jun 1995, published under WO 95/33480 on 14 Dec 1995
Related Technologies: DHHS Reference No. E-185-1992/2 --
U.S. Patent 6,451,763 issued 17 Sep 2002, entitled "Retinal Pigmented Epithelium Derived Neutrophic Factor and Methods of Use," by J Tombran-Tink, GJ Chader, SP Becerra, IR Rodriguez, FR Steele, and LV Johnson
DHHS Reference No. E-185-1992/3 --
U.S. Patent 6,319,687 issued 20 Nov 2001, entitled "Pigment Epithelium-Derived Factor: Characterization, Genomic Organization and Sequence of PEDF Gene," by GJ Chader, SP Becerra, J Tombran-Tink, LV Johnson, FR Steele, and I Rodriguez
Relevant Publication: T Taniwaki, SP Becerra, GJ Chader, JP Schwartz. Pigment epithelium-derived factor is a survival factor for cerebellar granule cells in culture. J Neurochem. 1995 Jun;64(6):2509-2517. [PubMed abs]
Licensing Status: Available for exclusive or nonexclusive licensing
For Additional Information Please Contact: Susan S. Rucker J.D.
NIH Office of Technology Transfer
6011 Executive Blvd, Suite 325
Rockville, MD 20852-3804
Phone: (301) 435-4478
Email: ruckersu@mail.nih.gov
Fax: (301) 402-0220
